| Project/Area Number |
11555243
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Synthetic chemistry
|
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| Research Institution | Institute for Molecular Science (2000-2001)
Nagoya City University (1999) |
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Principal Investigator |
UOZUMI Yasuhiro Institute for Molecular Science Professor, 分子科学研究所, 教授 (90201954)
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| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥11,300,000 (Direct Cost: ¥11,300,000)
Fiscal Year 2001: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | ansition metal catalysts / palladium-phosphine complexes / amphiphilic solid support / organic transformation in water / PS-PEG resin / palladium catalysis / PS-PEGレジン |
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| Research Abstract |
Owing to increasing environmental concerns about harmful and resource-consuming solvent waste, the chemistry of organic transformations in water is presently undergoing very rapid growth. On the other hand, development of immobilized reagents has been attracting significant interest for their practical advantages. There is good reason to believe that immobilized catalysts exhibiting high catalytic activity in aqueous media offer a viable clean alternative to more traditional methods of accomplishing many organic reactions. We have examined design and preparation of amphiphilic resin-supported triarylphosphine-palladium complexes bound to a polyethylene glycol-polystyrenegraft copolymer (PEG-PS resin) which exhibit high catalytic activity in allylic substitution reactions of allyl acetates with various nucleophiles in aqueous media under mild reaction conditions. As a part of our efforts to develop the wide utility of these catalysts, the palladium-catalyzed cross-coupling reaction and palladium-catalyzed hydroxycarbonylation in water were also successfully examined.
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