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Development of Biocompatible Silk Nonwoven Fabrics

Research Project

Project/Area Number 11556011
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field 蚕糸・昆虫利用学
Research InstitutionHeian Jogakuin College

Principal Investigator

ITO Hiraku  Heian Jogakuin College, Professor, 生活学科, 教授 (20213077)

Co-Investigator(Kenkyū-buntansha) ISHIKO Shoukyuu  Daiouin Sankenshi Institute, Manager, 所長(研究職)
HYON Suong-hyu  Institute for Frontier Medical Science, Kyoto University, Associate Professor, 再生医科学研究所, 助教授 (90283655)
SAKAI Hiroshi  Heian Jogakuin College, Lecturer, 生活学科, 講師 (90310648)
SUZUKI Shigehiko  Kagawa Medical University, Professor, 形成外科, 教授 (30187728)
SASAKI Hiroaki  Hiroaki, Niigata Women's College, Professor, 生活学科, 教授 (20123218)
IMAMURA Toshikatsu  Institute of Aseptic Sericulture, Manager, 無菌養蚕研究所, 所長(研究職)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥11,600,000 (Direct Cost: ¥11,600,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1999: ¥9,500,000 (Direct Cost: ¥9,500,000)
KeywordsSilk Nonwoven Fabric / Sankenshi / Needle Punching / Animal Experiment / Foreign Body Reaction / Absobability / Biocompatibility
Research Abstract

Tissue biocompatiblity of sik nonwoven fabrics was examined by in vivo test. Two types of nonwoven fabrics were used as sample material. One is produced from silk fibers from usual cocoon by using the nonwoven forming process (P type). The other is natural nonwoven fabric (so called "Sankenshi : S type), which was directly produced by the special silkworms of "Ishiko-san". This silkworms have a characteristics to produce flat type cocoon (Sankenshi) instead of usual type cocoon. In the animal experiments (in this work rabbit), the skin defect of 10×7 cm was created in the back, and the nonwoven samples (3×3cm) were implanted on the defect under contacting with subcutaneous tissue. In vivo test results showed that both types of nonwoven fabrics have very little foreign body reaction, namely have good biocompatibility. In addition, these samples induced a good effect for the healing of skin wound. These samples were not absorbed after 4 weeks implantation. Silk nonwoven fabrics are expected to become a useful tissue biocompatible implant material.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] H.Ito,H.Sasaki et al.: "Dyeing behavior of silk proteins in relation to Silkworn diet"Textile Res.J.. 69. 825-828 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sasaki,H.Ito et al.: "Dyeing Kinetics of CI Acid Orange 7 in Multiple Layers of a Chemically Modified Wool Fabric"Textile Res.J.. 69. 944-948 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ohta,S.-H.Hyon et al.: "Wear resistance of lightly cross-linked ultrahigh-molecular-weight polythylene crystallized from the melt"Wear. 225. 312-318 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sasaki,H.Ito et al.: "Dyeing properties of silk produced by silkworns reared on artificial and mulberry leaf diets"J.Soc.Dyer Colourists. 116. 349-351 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Matsumura,S.-H.Hyon et al.: "Surface Modification of Poly (ethylene-vinyl alchohol)(EVA) Part I.Introduction of Carboxyl Groups and"J.Biomed.Mater.Res.. 50. 512-517 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ohta,S.-H.Hyon et al.: "Dynamic Modulus Measurements of a Slightly Cross-linked Ultra-high Molecular Weight Polyethylene Crystallized"Russian J.Biomechanics. 51. 653-641 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Kunou,S.-H.Hyon et al.: "Biodegradable Scleral Implant for Controlled Intraocular Delivery of Betamethasone Phosphate"J.Control Release. 51. 653-641 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ohta,S.-H.Hyon,J.Nakamura et al.: "Development of artificial articular cartilage"Journal of Engineering in Medicine. 24. 59-68 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.-H.Hyon,D.-H.Kim: "Long-term preservation of rat pancreatic islets under physiological conditions"J.Biotech. 85. 241-246 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kasahara,H.Sasaki,N.Donkai et al.: "Dyeing properties of modified Tencel yarn with treatment of ferric sodium tartrate complex solution"J.Soc.Dyer Colourist. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Ito,T.Imamura,H.Sasaki et al.: "Structure and properties of newly developed silk"Proc.The 10th Int.Wool Textile Res.Conf., Aachen. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakashima,H.Ito,M.Matsuo et al.: "Antibacterial activity of cellulose fibers modified with metallic salts"Textile Res.J.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakashima,H.Ito,M.Matsuo et al.: "Biodegradation of high strength and high modulus PE-starch composite films buried in several kinds of soils"J.Macromol.Sci.Phys.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakashima,H.Ito,M.Matsuo et al.: "Biodegradation of biaxially stretched PE-starch composite films buried in several kinds of soils"J.Macromol.Sci.Phys.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Murakami,S.Iio,H.Ito et al.: "Effect of silane coupling agent on natural rubber filled with silica generated in situ"Rubber Chemistry and Technology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kasahara,H.Sasaki,N.Donkai,H.Ito et al.: "Swollen Behavior of Cellulosic Fibers Measured by Inverse Liquid Chromatography"Textile Res.J.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sasaki,N.Donkai,H.Ito.T.Baba: "Swollen behavior and dyeing properties of corona discharged wool yarn"Textile Res.J.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Oka,S.-H.Hyon, M.Ohta et al.: "Methods to reduce the wear of UHMWPE"Springer, Tokyo, Ed.by S.Imura. 10 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Ito, H.Sasaki, T.Imamura, H.Mori and F.Matsubara: "Dyeing behavior of silk proteins in relation to silkworm diet"Textile Res.J. 69. 825-828 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sasaki, H.Morikawa, H.Ito: "Dyeing Kinetics of CI Acid Orange 7 in Multiple Layers of a Chemically Modified Wool Fabric"Textile Res.J.. 69. 944-948 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ohta, S.-H.Hyon, M.Oka, and S.Tsutsumi: "Wear resistance of lightly cross-linked ultrahigh-molecular-weight polythylene crystallized from the melt under uniaxial compression"Wear. 225. 312-318 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sasaki, N.Donkai, H.Ito, K.Imamura, H.Morikawa: "Dyeing properties of silk produced by silkworms reared on artificial and mulberry leaf diets"J.Soc.Dyer Colourists. 116. 349-351 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Matsumura, S.-H.Hyon, N.Nakajima, and S.Tsutsumi: "Surface Modification of Poly (ethylene-vinyl alchohol)(EVA). Part I.Introduction of Carboxyl Groups and Immobilization of Collagen"J.Biomed.Mater.Res.. 50. 512-517 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ohta, S.-H.Hyon, T.-B.Kang, S.Tsutsumi, M.Oka, S.Murakami, S.Kohjiya: "Dynamic Modulus Measurements of a Slightly Cross-linked Ultra-high Molecular Weight Polyethylene Crystallized under Uniaxial Compression"Russian J.Biomechanics. 3. 34-48 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Kunou, Y.Ogura, Y.Honda and S.-H.Hyon: "Biodegradable Scleral Implant for Controlled Intraocular Delivery of Betamethasone Phosphate"J.Control Release. 51. 653-641 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Oka, K.Ushio, P.Kumar, K.Ikeuti, S.-H.Hyon, J.Nakamura, H.Fujita: "Development of artificial articular cartilage"Journal of Engineering in Medicine. 214. 59-68 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.-H.Hyon, D.-H.Kim: "Long-term preservation of rat pancreatic islets under physiological conditions."J.Biotech.. 85. 241-246 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kasahara, H.Sasaki, N.Donkai, Y.Yoshihara, H.Ito and T.Takagishi: "Dyeing properties of modified Tencel yarn with treatment of ferric sodium tartrate complex solution"J.Soc.Dyer Colourist. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Ito, T.Imamura, H.Sasaki, N.Donkai, K.Uemura and M.Yoshida: "Structure and properties of newly developed silk"Proc.The 10th Int.Wool Textile Res.Conf., Aachen. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakashima, Y.Sakagami, H.Ito, M.Matsuo: "Antibacterial activity of cellulose fibers modified with metallic salts"Textile Res.J.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakashima, H.Ito, M.Matsuo: "Biodegradation of high strength and high modulus PE-starch composite filmsburied in several kinds of soils"J.Macromol.Sci., Phys.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakashima, H.Ito, M.Matsuo: "Biodegradation of biaxially stretched PE-starch composite films buried in several kinds of soils"J.Macromol.Sci., Phys.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Murakami, S.Iio, Y.Ikeda, H.Ito, M.Tosaka, and S.Kohjiya: "Effect of silane coupling agent on natural rubber filled with silica generated in situ"Rubber Chemistry and Technology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kasahara, H.Sasaki, N.Donkai, H.Ito, T.Yoshihara, T.Takagishi: "Swollen Behavior of Cellulosic Fibers Measured by Inverse Liquid Chromatography"Textile Res.J.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sasaki, N.Donkai, H.Ito, T.Baba: "Swollen behavior and dyeing properties of corona discharged wool yarn"Textile Res.J.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sasaki,H.Ito et al.: "Dyeing properties of silk produced by silkworms reared on artificial and mulberry leaf diets"J.Soc.Dyer Colourists. 116. 349-351 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Matsumura,S.-H.Hyon,N.Nakajima et al.: "Surface Modification of Poly (ethylene-vinyl alchohol)(EVA).Part I. Introduction of Carboxyl Groups and"J.Biomed.Mater.Res.. 50. 512-517 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Ohta,S.-H.Hyon et al.: "Dynamic Modulus Measurements of a Slightly Cross-linked Ultra-high Molecular Weight Polyethylene"Russian J.Biomechanics. 3. 34-48 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Kunou,S.-H.Hyon et al.: "Biodegradable Scleral Implant for Controlled Intraocular Delivery of Betamethason Phosphate"J.Control Release. 51. 653-641 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Ohta,S.-H.Hyon et al.: "Development of artificial articular cartilage"Journal of Engineering in Medicine. 214. 59-68 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.-H.Hyon,D.-H.Kim: "Long-term preservation of rat pancreatic islets under physiological conditions"J.Biotech. 85. 241-246 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Kasahara,H.Sasaki,N.Donkai et al.: "Dyeing properties of modified Tencel Yarn with Treatment of ferric sodium tartrate complex solution"J.Soc.Dyer Colourist. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Ito,T.Imamura,H.Sasaki et al.: "Structure and properties of newly developed silk"Proc.The 10th Int.Wool Textile Res.Conf.,Aachen. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Nakashima,H.Ito,M.Matsuo et al.: "Antibacterial activity of cellulose fibers modified with metallic salts"Textile Res.J.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Nakashima,H.Ito,and M.Matsuo : "Biodegradation of high strength and high modulus PE-starch composite filmsburied in several kinds of"J.Macromol.Sci.,Phys.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Nakashima,H.Ito,M.Matsuo: "Biodegradation of biaxially stretched PE-starch composite films buried in several kins of soils"J.Macromol.Sci.,Phys.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Murakami,S.Iio,H.Ito,Y.Ikeda et al.: "Effect of silane coupling agent on natural rubber filled with silica generated in situ"Rubber Chemistry and Technology. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Oka,S.-H.Hyon,M.Ohta et al.: "Methods to reduce the wear of UHMWPE"Springer, Tokyo, Ed.by S.Imura. 10 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Ito,H.Sasaki,T.Imamura: "Dyeing behavior of silk proteins in relation to silkworm diet"Textile Research Journal. 69-11. 825-828 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Sasaki,N.Donkai,H.Ito,T.Imamura: "Dyeing properties of silk produced by the silkworms reared on artificial and mulberry leaf diet"Journal of the Society of Dyers and Colourists. (in press). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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