| Project/Area Number |
11556059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Applied veterinary science
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| Research Institution | THE UNIVERSITY OF TOKYO |
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Principal Investigator |
DOI Kunio GRADUATE SCHOOL OF AGRICULTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO, PROFESSOR, 大学院・農学生命科学研究科, 教授 (70155612)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Hiroyuki GRADUATE SCHOOL OF AGRICULTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO, ASSOC. PROFESSOR, 大学院・農学生命科学研究科, 助教授 (40155891)
SASAKI Nobuo GRADUATE SCHOOL OF AGRICULTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO, PROFESSOR, 大学院・農学生命科学研究科, 教授 (60107414)
ONO Ken-ichiro GRADUATE SCHOOL OF AGRICULTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO, PROFESSOR, 大学院・農学生命科学研究科, 教授 (50111480)
KIMURA Tohru RESEARCH CENTER OF NIHON NOSAN KOGYO CO., CHIEF RESEARCHER, 中央研究所, 主任研究員
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2000: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1999: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | Laboratory hairless dogs / Dermatosurgery / Burn wound / Wound dressing / Q-switched ruby laser / Depigmentation / Rejuvenation / 実験用ヘアレス犬 / 背部皮膚 / 創傷被覆材 / 絹フィブロイン / spotty pigmentation / Q-switched ruby laser / 創傷被覆材の評価系 / キチン製材 / キトサン製材 / hairless dog / split thickness wound / wound dressing |
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| Research Abstract |
Usefulness of laboratory hairless dogs (LHDs) in the field of dermatosurgery was investigated. As a result, it was clarified that LHDs were useful as a burn wound or skin injury healing model and efficacy and safety of several kinds of wound dressings were examined using these models. In addition, it was shown that LHDs were useful for the evaluation of efficacies of Q-switched ruby laser irradiation and hydroquinone on senile spotty pigmentation. Moreover depigmentation and rejuvenation effects of all-trans-retioic acid and kinetin on senile dorsal skin of LHDs were investigated, suggesting a usefulness of LHDs in those experiments.
Thus the usefulness of LHDs in the field of dermatosurgery was clarified.
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