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Research and Development of Neuroprotective Drugs Based on the Neuron-Glia Interactions

Research Project

Project/Area Number 11557004
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field General pharmacology
Research InstitutionOsaka University

Principal Investigator

BABA Akemichi  Osaka Univ., Grad. Sch. of Pharmaceutical Sci. Prof., 薬学研究科, 教授 (70107100)

Co-Investigator(Kenkyū-buntansha) KOYAMA Yutaka  Osaka Univ., Grad. Sch. of Pharmaceutical Sci. Associate Prof., 薬学研究科, 助教授 (00215435)
SHIGENAGA Yoshio  Osaka Univ., Grad. Sch. of Dentistry. Prof., 歯学研究科, 教授 (90028770)
MATSUDA Toshio  Osaka Univ., Grad. Sch. of Pharmaceutical Sci. Prof., 薬学研究科, 教授 (00107103)
HASHIMOTO Hitoshi  Osaka Univ., Grad. Sch. of Pharmaceutical Sci. Associate Prof., 薬学研究科, 助教授 (30240849)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2000: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1999: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsBrain injury / Microglia / Astrocyte / Nerve Degeneration / Apoptosis / 脳障害
Research Abstract

Neuroprotective Actions of Novel Drugs; SEA400, a Na/Ca exchange inhibitor decreased the brain infract volume induced by MCA occlusion (Jpharmacol. Exp. Ther., 298,249-256,2001). SEA400 also had an inhibitory effect on brain edema (increases in water content) in heat lesion-induced brain injury. The anti-edema effect was partly brought from protection of BBB. T-588, a novel drug aimed for therapy of Alzheimer disease, prevented damages of cultured astrocytes by oxidartive stress, which was mediated by the activation of ERK (extracellular-regulated protein kinase) (Eur. Jpharmacol 399,1-8,2000). Injection of T-588 increased ERK activity in rat brain. An immunochemical study, showed that the increase in ERK activation by T-588 is due to the neuronal component. These findings suggest a possibility that SEA400 and T-588 could be neuroprotective drugs against brain injury and neurodegenerative diseases.
Mechanisms of Glial Death; Serum-deprivation-induced death of cultured microglia was mediated by expression: of Bax, an pro-apoptotic protein (Jpn. Jpharmacol. 83,351-154,2000). Mechanisms of apoptosis of cultured astrocytes were examined. We found that induction of astrocytes apoptosis was closely related with reduction of mitochondrial membrane potential. Several drugs (T-588, Ibudilast, CV-2619.SEA400) prevented. The astrocytic apoptosis Br.Jpharmacol., 133,841-578, 2001; Jpharmacol. Exp. Ther., 298,249-256,2001). Intracelluair signals mediated by cGMP were involved in the regulation mitochondrial membrane potential to protect astrocytic apoptosis.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (100 results)

All Other

All Publications (100 results)

  • [Publications] 馬場明道: "グリア細胞の活性化とグリア細胞死"最新医学. 54. 75-78 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 松田敏夫: "グリア細胞の障害と保護"日薬理誌. 114. 281-286 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋京子: "Angiotensin II誘導による心肥大に対する「丹参」の作用"心筋の構造と代謝. 145-152 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 馬場明道: "脳内の大麻(マリファナ)"脳21. 2. 377-382 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "BQ788, an endothelin ET_B receptor antagonist, attenuates stab wound injury-induced reactive astrocyes in rat brain"Glia. 26. 268-271 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes : Its relationship to cytoskeletal actin organization"Glia. 26. 324-332 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPACl) receptor"Genomics. 58. 90-93 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelins stimulate expression of cyclooxygenase 2 in rat cultured astrocytes"J. Neurochem. 73. 1004-1011 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "Apoptosis in Ca^<2+> reperfusion injury of cultured astrocytes : roles of reactive oxygen species and NF-kB activation"Eur. J. Neurosci. 11. 4204-4212 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 小山 豊: "グルタミン酸トランスポーター"蛋白質 核酸 酵素. 45. 1133-1139 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 橋本 均: "ニューロペプチドPACAPによる体内時計の調節機構"ファルマシア. 36. 813-814 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 橋本 均: "ニューロペプチドPACAP受容体の構造と機能"別冊医学のあゆみ. 79-84 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Transient treatments with L-glutamate and threo-β-hydroxyaspartate induce swelling of rat cultured astrocytes"Neurochem. Int.. 36. 167-173 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expressiong by nerve growth factor and PACAP in PC12 cells"J. Neurochem.. 74. 501-507 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied with their association with cytoskeletal components"Neuroscience. 101. 219-227 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "L-lactate inhibits L-cystine/L-glutamate exchange transport and decreases glutathione content in rat cultured astrocyes"J. Neurosci. Res.. 59. 685-691 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masaki Sakaue: "Postsynaptic 5-hydroxytryptaminelA receptor activation increases in vivo dopamine release in rat prefrontal cortex"Br. J. Pharmacol.. 129. 1028-1034 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroaki Nakamura: "The Na^+-Ca^<2+> exchange inhibitor KB-R7943 inhibits high K^+-induced increases in intracellular Ca^<2+> concentration and [^3H] noradrenaline release in the human neuroblastoma SH-SY5Y"Neurochem. Res.. 25. 385-387 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masaki Sakaue: "The Na^+-Ca^<2+> exchanger isoforms in rat neuronal preparations : different changes in their expression during postnatal development"Brain Res.. 881. 212-216 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhito Takuma: "T-588 inhabits astrocyte apoptosis via mitogen-activated protein kinase signal pathway"Eur. J. Pharmacol. 399. 1-8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Serum-deprivation induces cell death of rat cultured microglia accompained with expression of bax protein"Jpn. J. Pharmacol. 83. 351-354 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Mice with markedly reduced PACAP(PAC_1) receptor expression by targeted deletion of the signal peptide"J. Neurochem.. 75. 1810-1817 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Norihito Shintani: "Desensitization, surface expression, and glycosylation of a functional, epitope-tagged type IPACAP(PAC_1) receptor"Biochim. Biophy. Acta. 1509. 195-202 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelin ET_B receptors in glial cells : a new target for neurotrophic drugs"Current Topics In Pharmacology. 5. 119-127 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production"Eur. J. Pharmacol. 406. 333-339 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Naohisa Arakawa: "KB-R7943 inhibits store-operated Ca^<2+> entry in cultured neurons and astrocytes"Biochem. Biophys. Res. Comm.. 279. 354-357 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 小山 豊: "脳とエンドセリン"脳21. 4. 73-78 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 橋本 均: "ニューロペプチドPACAPの生理的役割とそのしくみ"生化学. 72. 191-193 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 馬場明道: "PACAP"生体の科学. 52. 359 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 小山 豊: "アクアポリン-4と脳浮腫"日薬理誌. 118. 289 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "Ibudilast attenuates astrocyte apoptosis via cyclic GMP signaling pathway in an in vitro reperfusion model"Br. J. Pharmacol. 133. 541-548 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "Signal cascade of Na/Ca exchanger-involved delayed apoptosis of astrocytes"Control and Diseases of Sodium Department Transport Proteins and Ion Channels. 87-88 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Alteration of brain dopaminergic system in isolated aggressive mice"Jpn. J. Neuropsychopharmacol. 21. 71-76 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masaki Sakaue: "Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT1A receptor activation in isolated mice"Eur. J. Pharmaacol.. 432. 163-166 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide(PACAP)"Proc. Natl. Acad. Sci. USA. 98. 13355-13360 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "Anti-apoptotic effect of cGMP in cultured astrocytes : inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore"J. Biol. Chem.. 276. 48093-48099 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshiyuki Sakai: "Involvement of p38 MAP Kinase Pathway in the Synergistic Activation of PACAP nRNA Expression by NGF and PACAP in PC12h Cells"Biochem. Biophys. Res. Comm. 285. 656-661 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshio Matsuda: "SEA0400, a novel and selective inhibitor of the Na^+-Ca^<2+> exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebrial ischemic models"J. Pharmacol. Exp. Ther. 298. 249-256 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Signaling pathways to prevent astrocyte apotosis"Recent Res. Devel. Neurochem. 4. 89-96 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "Anti-apoptotic andcytotoxic effects of the nitric oxide donor NOC12 in cultured rat astrocytes"Jpn. J. Pharmacol.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 小山 豊: "脳傷害時のアストログリアの機能変化とその細胞内機構"日薬理誌. 119. 135-143 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Baba A.: "Glial activation and death"Saishinn-lgaku. 54. 75-78 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuda T.: "Damages and protection of glial cels"Folia Pharmacol. Japonica. 114. 281-286 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi K.: "Effect of tan-jin on angiotensin II-induced cardiac hypertrophy"Shinkin-no-kouzou to taisha. 145-152 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Baba A.: "Brain marihuana"Nou-21. 2. 377-382 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "BQ788, an endothelin ET_B receptor antagonist, attenuates stab wound injury-induced reactive astrocytes in rat brain"Glia. 26. 268-271 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Endothelin-induced protein tyrpsine phosphorylation of cultured astrocytes: It s relationship to cytoskeletal actin organization"Glia. 26. 324-332 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashimoto H.: "Genomic organization and chromosomal location of the mouse vasoactive intestinal polvpeptide 1 (VPAC1) receptor"Genomics. 58. 90-93 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Endothelins stimulate expression of cyclooxygenase 2 in rat cultured astrocytes"J. Neurochem.. 73. 1004-1011 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "Apoptosis in Ca^<2+> reperfusion injury of cultured astrocytes : roles of reactive oxygen species and NF-κB activation"Eur. J. Neurosci.. 11. 4204-4212 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Glutamate transporters"Tanpakushitu Kakusann Kohso. 45. 1133-1139 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashimoto H.: "Regulation circadiam clock by neuropeptide, PACAP"Farumashia. 36. 813-814 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashimoto H.: "Structure and functions of PACAP receptors"Igaku no Ayumi. 79-84 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Transient treatments with L-glutamate and threo-β-hydroxyaspartate induce swelling of rat cultured astrocytes"Neurochem. Int.. 36. 167-173 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashimoto H.: "Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells"J. Neurochem.. 74. 501-507 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "focal adhesion kinase and paxillin accompanied with their Endothelins increase tyrosine phosphorylation of astrocytic association with cytoskeletal components"Neuroscience. 101. 219-227 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "L-lactate inhibits L-cystine / L-glutamate exchange transport and decreases glutathione content in rat cultured astrocytes"J. Neurosci. Res.. 59. 685-691 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakaue M.: "Postsynaptic 5-hydroxytryptamin 1A receptor activation increases in vivo dopamine release in rat prefrontal cortex"Br. J. Pharmacol. 129. 1028-1034 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakamura H.: "The Na^+-Ca^<2+> exchange inhibitor KB-R7943 inhibits high K^+-induced increases in intracellular Ca^<2+> concentration and [3H] noradrenaline release in the human neuroblastoma SH-SY5Y"Neurochem. Res.. 25. 385-387 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakaue M.: "The Na^+-Ca^<2+> exchanger isoforms in rat neuronal preparations different changes in their expression during postnatal development"Brain. Res.. 881. 212-216 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "Serum-deprivation induces cell death of rat cultured microglia accompained with expression of bax protein"Eur. J. Pharmacol. 399. 1-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Serum-deprivation induces cell death of rat cultured microglia accompained with expression of Bax protein"Jpn. J. Pharmacol. 83. 351-354 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashimoto H.: "Mice with markedly reduced PACAP(PAC_1) receptor expression by targeted deletion of the signal peptide"J. Neurochem.. 279. 354-357 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shintani N.: "Desensitization, surface expression, and glycosylation of a functional, opitope-tagged type I PACAP (PAC_1) receptor"Biochim Biophy. Acta. 1509. 195-202 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Endothelin ET_B receptors in glial cells: a new target for neurotrophic drugs"Curr. Topics In Pharmacol. 15. 119-127 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production"Eur. J. Pharmacol. 406. 333-339 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Endothelin In brain"Nou-21. 4. 73-78 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashimoto H.: "Physiological roles of PACPA"Seikagaku. 72. 191-193 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Baba A.: "PACPA"Seita no kagaku. 52. 359 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Aquaorin-4 and brain edema"Folia Pharmacol. Japonica. 118. 289 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "Ibudilast attenuates astrocyte apoptosis via cyclic GMP signaling pathway in an in vitro reperfusion model"Br. J. Pharmacol. 133. 541-548 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "Signal cascade of Na/Ca exchanger-involved delayed apoptosis of astrocytes"Control and Diseases of Sodium Department Transport Proteins and Ion Channels. 87-88 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuda T.: "Alteration of brain dopaminergic system in isolated aggressive mice"Jpn. J. Neuropsychopharmacol. 21. 71-76 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakaue M.: "Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT1A receptor activation in isolated mice"Eur. J. Pharmaacol. 432. 163-166 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashimoto H.: "Altered psychomotor behaviors in mice lacking pituitary Adenylat cyclase-activating polypeptide (PACAP)"Proc. Natl. Acad. Sci USA. 98. 13355-13360 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore"J. Biol. Chem.. 276. 48093-48099 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakai Y.: "Involvement of p38 MAP Kinase Pathway in the Synergistic Activation of PACAP nRNA Expression by NGF and PACAP in PC12h Cells"Biochem. Biophys. Res. Comm.. 285. 656-661 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuda T.: "SEA0400, a novel and selective inhibitor of the Na-Ca exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebrial ischemic models"J. Pharmacol. Exp. Ther.. 296. 3249-256 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuda T.: "Signaling pathways to prevent astrocyte apotosis"Recent Res. Devel. Neurochem.. 4. 89-96 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koyama Y.: "Functional alterations of astrogiia on brain pathologies and their intracellular mechanisms"Folia Pharmacol. Japonica. 119. 135-143 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "Anti-apoptotic andcytotoxic effects of the nitric oxide donor NOC12 in cultured rat astrocytes"Jpn. J. Pharmacol. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takuma K.: "Ibudilast attenuates astrocyte apoptosis via cyclic GMF signaling pathway in an in vitro reperfusion model"Br. J. Pharmacol.. 133. 541-548 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matusda T.: "SEA0400, a novel and selective inhibitor of the Na^+ -Ca^<2+> exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models"J. Pharmacol. Exp. Ther.. 298. 249-256 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takuma K.: "Anti-apoptotic effect of cGMP in cultured astrocytes : inhibition by cGMP-dependent protein kinase of mitochondria permeable transition pore"J.Biol.Chem.. 276. 48093-48099 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakai Y.: "Involvement of p38 MAP Kinase Pathway in the Synergistic Activation of PACAP nRNA Expression by NGF and PACAP in PC12h Cells"Biochem.Biophys.Res.Commum.. 285. 656-661 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takuma K.: "Anti-apoptotic andcytotoxic effects of the nitric oxide donor NOC12 in cultured rat astrocytes"Jpn.J.Pharmaco. (in press). 685-691 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小山 豊: "脳傷害時のアストログリアの機能変化とその細胞内機構"日薬理誌. 119. 135-143 (2002)

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  • [Publications] Takuma K.: "T-588 inhibits astrocytic apoptosis via mitogen-activated protein kinase pathway."Eur.J.Pharmacol. 399. 1-8 (2000)

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  • [Publications] Nakamura H.: "The Na^+-Ca^<2+> exchange inhibitor KB-R7943 inhibits high K^+-induced increases in intracellular Ca^<2+> concentration and ^3H-noradrenaline release in the human neuroblastoma SH-SY5Y"Neurochem.Res.. 25. 354-357 (2000)

    • Related Report
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  • [Publications] Sakaue M,: "Na^+-Ca^<2+> exchanger isoforms in rat neuronal preparations : different changes in their expression during postnatal development."Brain Res.. 881. 212-216 (2000)

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  • [Publications] Arakawa N.: "KB-R7943 inhibits store-operated Ca^<2+> entry in cultured neurons and astrocytes."Biochem.Biophys.Res.Commun.. 279. 354-357 (2000)

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  • [Publications] Koyama Y.: "L-Lactate inhibits L-cystine/L-glutamate exchange transport and decreases glutathione contents in rat cultured astrocytes."J.Neurosci.Res.. 59. 685-691 (2000)

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  • [Publications] Koyama Y.: "Transient treatments with L-glutamate and threo-β-hydroxy-aspartate induced swelling of rat cultured astrocytes."Neurochem.Int.. 36. 167-173 (2000)

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  • [Publications] Koyama Y.: "Eudothelins increase tyrosine phosphorylation of astroytic focal adhesion kinase and paxillin accompanied with their association with cytoskeletal components."Neuroscience. 101. 219-227 (2000)

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  • [Publications] Koyama Y.: "Serum-deprivation induces cell death of rat cultured microglia accompanied with expression of bax protein."Jpn.J.Pharmacol.. 83. 351-354 (2000)

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  • [Publications] 馬場明道: "グリア細胞の活性化とグリア細胞死"最新医学. 54・7. 75-78 (1999)

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      1999 Annual Research Report
  • [Publications] Yutaka Koyama: "BQ788,an endothelin ET_B receptor antagonist attenuates stab injury-induced reactive astrocytes in brain"Glia. 26. 268-271 (1999)

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      1999 Annual Research Report
  • [Publications] Kazuhiro Takuma: "Apoptosis in Ca^<2+> reperfusion injury of cultured astrocytes : roles of reactive oxygen species and NF-κB activation"Eur.J.Neurosci.,. 11. 4204-4212 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yutaka Koyama: "L-lactate inhibits L-cystine/L-glutamate exchange transport and decreases glutathione content in rat cultured astrocytes"J.Neurosci.Res.,. in press. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hitoshi Hashimoto: "Synergistic induction of pituitary adenylate cyclase-activating polypeptide(PACAP) gene expression by growth factor and PACAP in PC12 cells"J.Neurochem.,. 74・2. 501-507 (2000)

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      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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