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Functional analysis of the non-HLA genes within major histocompatibility complex (MHC) region with the use of gene-targeted mice

Research Project

Project/Area Number 11557013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokushima

Principal Investigator

MATSUMOTO Mitsuru  The University of Tokushima, Institute for Enzyme Research, Professor, 分子酵素学研究センター, 教授 (60221595)

Co-Investigator(Kenkyū-buntansha) MATSUSHIMA Akemi  The University of Tokushima, Institute for Enzyme Research, Lecturer, 分子酵素学研究センター, 教務員 (70116862)
YORITA Kazuko  The University of Tokushima, Institute for Enzyme Research, Assistant Professor, 分子酵素学研究センター, 助手 (60116879)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2001: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2000: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1999: ¥6,800,000 (Direct Cost: ¥6,800,000)
Keywordscomplex / Autoimmune disease / Disease susceptibility / Knockout mice / 主要組織適合複合体 / 疾患感受性遺伝子 / 生体防御機構 / 炎症
Research Abstract

Since the discovery of the relationship between the geno-types of major histocompatibility complex (MHC) and susceptibility to many diseases, including autoimmune diseases, functional analysis of the genes within MHC region has been considered to be one of the most important issues for the better understanding of the processes involved in the development of many diseases. In order to reveal the mechanisms underlying the relationship between major histocompatibility complex (MHC)-type and disease susceptibility, we have been working on the generation of mice in which immune-related genes within the MHC region are deleted (knockout mice) with the use of gene-targeting technology. In this study, we have especially focused on the analysis of two genes near the TNF/lymphotoxin locus, because this locus contains many genes relevant to the development of inflammation. For one gene, chimeric mice have been generated, and the targeting vector has been constructed for the other gene, We are now in the process of generation of knockout mice for these two genes, We believe that analysis of the phenotype of these mice will also lead to a clear understanding of the function of the genes relevant to the host defence mechanism.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Matsushima, A., et al.: "Essential role of NF-κB-inducing kinase and IκB-kinase α in NF-κB activation through lymphotoxin-βreceptor, but not through TNF receptor-I"Journal of Experimental Medicine. 193. 631-636 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada, T., et al.: "Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-κB-inducing kinase"Journal of Immunology. 165. 804-812 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsumoto, M., et al.: "Involvement of distinct cellular compartments in the abnorinal lymphoid organogenesis in lymphotoxin-α-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis"Journal of Immunology. 163. 1584-1591 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsumoto, M.: "Role of TNF ligand and receptor family in the lymphoid organogesis defined by gene targeting"Journal of Medical Investigation. 46. 141-150 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakano, H., et al.: "Targeted disruption of Traf5 gene causes defects in CD4O-and CD27 mediated lymphocyte activation"Proc. Natl. Acad. Sci. USA. 96. 9803-9808 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsushima,A. et al.: "Essential role of NF-κB-inducing kinase and iκB-kinase α in NF-κB activation through Iymphotoxin-β receptor, but hot through TNF receptor-1"Journal of Experimental Medicine. 193. 631-636 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada,T. et al.: "Abnormal immune function of Herndpoietic cells from alymphoplasla (aly) mice, a natural strain with mutant NF-κB-inducing kihase"Journal of Immunology. 165. 804-812 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsumoto,M. et al.: "Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-a-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis"Journal of immunology. 163. 1584-1591 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsumoto,M.: "Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting"Journal of Medical Investigation. 46. 141-150 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakano,H. et al: "Targeted disruption of Traf5 gene causes defects in CD40- and CD27 mediated lymphocyte activation"Proc. Natl, Acad, Sci. USA. 96. 9803-9808 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsushima, A. et al.: "Essential role of NF-κB-inducing kinase and IκB-kinase α in NF-κB activation through lymphotoxin-β receptor, but not through TNF receptor-I"Journal of Experimental Medicine. 193(5). 631-636 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamada,T., et al: "Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-κB-inducing kinase."Journal of Immunology. 165. 804-812 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsushima,A., et al.: "Essential role of NF-κB-inducing kinase and IκB-kinase α in NF-κB activation through lymphotoxin-β receptor, but not through TNF receptor-I"Journal of Experimental Medicine. 193(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsumoto,M.,et al.: "Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-α-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis"J.Immunol.. 163. 1584-1591 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakano,H.,et al.: "Targeted disruption of Traf5 gene causes defects in CD40-and CD27-mediated lymphocyte activation."Proc.Natl.Acad.Sci.USA. 96. 9803-9808 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsumoto,M.: "Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting."J.Med.Invest.. 46. 141-150 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松本 満: "ノックアウトマウスを用いたMHC領域内non-HLA遺伝子機能の解析"生化学. 71. 323-332 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松本 満: "リンパ組織の形成におけるリンホトキシンとTNFの役割:ノックアウトマウスを用いた研究から得られた知見を中心に"日本リンパ網内系学会会誌. 38. 31-41 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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