| Project/Area Number |
11557034
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Legal medicine
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| Research Institution | Mie University |
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Principal Investigator |
TANEGASHIMA Akio Mie University Faculty of Medicine, Lecturer, 医学部, 講師 (70283520)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hidetaka Mie University, Faculty of Medicine, Assistant, 医学部, 助手 (90158296)
FUKUNAGA Tatsushige Mie University, Faculty of Medicine, Professor, 医学部, 教授 (70156800)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | child abuse / neglect / thymus / stress / parathymic lymph node / intrathymic lymph node / Le^Y / high endothelial venule / child abase / parathymic lymph node / high endethelial venule / child neglect / abuse / Immunity / lymph node |
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| Research Abstract |
It is difficult to evaluate the extent of stress in cases of suspected child abuse/neglect in a medico-legal autopsy. To elucidate the influence upon thymocytes differentiation, we investigated that the morphological change of the thymus and the proportion of the thymocyte subpopulation in abused/neglected children. We found that the relative number of CD4+CD8+ double positive (DP) thymocytes decreased in the abused/neglected children. It was presumed that the selective decrease in the number of the immature DP thymocytes with CD3 ^<- to low> bcl-2^<low> caused the thymic involution in the abused/neglected children. It is proposed that the alteration in the proportion of thymocyte subpopulations could be an index for the degree of the stress in cases of child abuse/neglect.
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