| Project/Area Number |
11557096
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TSUTSUI Tatsuo Institute of Clinical Medicine, University of Tsukuba Associate Professor, 臨床医学系, 助教授 (50112868)
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| Co-Investigator(Kenkyū-buntansha) |
SANKAI Yoshiyuki Mechanics & Systems Institute of Engineering, University of Tsukuba Associate Professor, 機能工学系, 助教授 (30183833)
SHIGETA Osamu Institute of Clinical Medicine, University of Tsukuba Associate Professor, 臨床医学系, 講師 (10196371)
JIKUYA Tomoaki Institute of Clinical Medicine, University of Tsukuba Associate Professor, 臨床医学系, 講師 (20231368)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2000: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥8,700,000 (Direct Cost: ¥8,700,000)
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| Keywords | continuous flow artificial heart / mono-pivot / flow visualization / adaptation physiology / autonomic nervous system / remote monitoring / remote control / telemetry |
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| Research Abstract |
The purposes of this study are the development of continuous flow artificial heart, the evaluation of the adaptation status of living bodies to continuous flow circulation, and the development of remote monitoring and control system for living bodies with artificial hearts.
For the determination of antithrombogenic design of continuous flow artificial heart, we adopted flow visualization method and animal experiments using 9 sheeps. The comparison of results of flow visualization study and anmal experiments show good correlation on the sites of thrombi formation. This strategy shortened the duration of investigation for optimal design of the continuous flow artificial heart.
As a fundamental research, activities of autonomic nervous system was evaluated using power spectrum analysis of arterial pressure waves in clinical cases with mechanical circulatory support including continuous flow blood pumps. The low frequncy (0.04-0.15Hz) values representing sympathetic nerve actoivities were hi
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ghly depressed in cases with poor clinical outcome. In animal experiments with continuous flow artificial heart, the low frequency values of arterial pressure power spectra were not depressed and those were stable during phalmacological arterial pressure perturbation. It means the sufficient adaptation of animals for addition of continuous flow circulation
Systems for remote monitoring of the animal with artificial heart and for remote control of the artificial heart were developed. Continuous monitoring of parameters including arterial and venous pressures, blood flow, body temperature. pump rotatioraal speed and energy consumption of the pump were able to be performed using World Wide Web. Moving photographs of the animals were also transmitted via Web. The remote control of pump rotational speed was successfully conducted also via the home page protected by passwords.
By application of the results of these studies, it becomes possible to continue more efficient and reliable research for the clinical application of continuous flow artificial heart for patients with severe circulatory disorders. Less
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