| Project/Area Number |
11557108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Teikyo Univ. School of Med. |
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Principal Investigator |
NAKAGONI Tadayoshi Teikyo Univ., School of Medicine, Professor, 医学部, 教授 (90198052)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANE Makoto Teikyo Univ., School of Medicine, Assistant, 医学部, 助手 (00266305)
KUBOTA Masaru Teikyo Univ., School of Medicine, Associate Professor, 医学部, 助教授 (30246061)
TAMURA Akira Teikyo Univ., School of Med., Professor, 医学部, 教授 (80111532)
MASUDA Hiroyuki Seikagaku Co. Ltd., Research Fellow, 生物研究室・主任研究員
INOGUCHI Jinichi Hokkaido Univ., Graduate School of Pharm., Associate Prof., 大学院・薬学研究科, 助教授 (70131810)
成田 孝而 帝京大学, 医学部, 助手 (90237602)
金光 秀晃 帝京大学, 医学部, 講師 (10129992)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2000: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1999: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | Sphingolipid / Focal ischemia / L-PDMP / Behavior / MCA / Glucosylceramide / Sphingomyelin / hypothermia / delay neuronal death / ganglioside / 中大脳動脈閉塞モデル / グルコシルセラミド / 水迷路 / セラミド / スフィンゴミエリン / ceramide / D-PDMP |
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| Research Abstract |
L-PDMP (L-threo-l-phenyl-2-decanoylamino-3-morpholino-l-propanol) exhibits stimulatory effects on glycosphingolipid biosynthesis and its neurotrophic actions in cultured neuron. The effects of intraperitoneal administration of L-PDMP on sphingolipid metabolism and behavioral changes in the rat following permanent occlusion of the left middle cerebral artery (MCA) were investigated. The L-PDMP treatment induced increases in glucosylceramide (ganglioside precursor) and sphingomyelin (SM) levels in the ischemic cerebral cortex, and improved acquisition of memory and learning in the Morris water maze task. The pharmacological effects of L-PDMP have been proposed to have a significant activity on promoting cell survival and improving neural functions.
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