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An experimental study on the feasibility of True Bone Ceramics for the anterior fusion of the spine

Research Project

Project/Area Number 11557110
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Orthopaedic surgery
Research InstitutionWakayama Medical University

Principal Investigator

TAMAKI Tetsuya  Wakayama Medical University, Professor, 医学部, 教授 (30009592)

Co-Investigator(Kenkyū-buntansha) YAMADA Hiroshi  Wakayama Medical University Assistant, 医学部, 助手 (70275361)
KAWAKAMI Mamoru  Wakayama Medical University, Lecturer, 医学部, 講師 (20195051)
永井 裕  高研バイオサイエンス研究所, 所長 (90013812)
吉田 宗人  和歌山県立医科大学, 医学部, 講師 (60201018)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2000: ¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1999: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsTrue Bone Ceramics / sintered bovine bone / anterior spinal fusion / Villanueva-Goldner Trichrome staining / サル / TBC(焼成骨) / TSRH Spinal System
Research Abstract

We have performed basic studies on the utilization of sintered bovine bone (True Bone Ceramic : TBC) for the anterior spinal fusion in pig model and revealed the feasibility of TBC as the bone substitute to obtain biological fusion between vertebrae. Although, the physical strength of the TBC is inferior to the biological bone, therefore it was deemed necessity to test the usefulness of the TBC under the condition of sustained compressive stress. For this purpose, 6 monkeys, which sustain sitting poison and bipedal standing, were used for present study. Implanted TBC was consisted with the monocortex on one side and cancellous structure, which is called monocortical-cancellous TBC.Under general anesthesia with extraperitoneal approach, the 5^<th> lumbar vertebra was excised and the block of the monocortical-cancellous TBC was implanted between L4 and L6. For the purpose of reinforcement a screw was inserted to the vertebral bodies of L4 and L6 and single rod was used to connect these two screws. X ray examination was performed at every 3 months and the alignment of the vertebrae and implanted TBC, clear zone at the recipient site and bone formation were carefully observed. No sign of pseudo-arthrosis and compressive deformity of the TBC were found. Extracted spines of L4 and L6 at 10 month after implantation showed 110Mpa in axial strength, 11.8 Nm/deg in torsional strength and 160Nm in compressive strength, which were regarded as sufficient strength. Histological study with Villanueva-Goldner Trichrome staining revealed new bone matrix was growing into the pores of deep layer of the implant and contacts with TBC without any intervening fibrous tissue. At 10 months after implantation, the amount of osteoid cell was small and majority of the space was occupied by newly formed bone. It appears, therefore, from these findings that the monocortical-cancellous TBC can be used for the anterior spinal fusion supplementing with a simple spinal instrumentation.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Minamide A.,Tamaki T., et al: "An experimental approach to spinal fusion using sintered bovine bone in a pig model"Journal of Spinal Disorders. 13(2). 156-164 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 南出晃人,玉置哲也 他: "焼成骨材料の脊椎固定術への応用に関する実験的研究"臨床整形外科. 34(4). 553-559 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 南出晃人,玉置哲也 他: "脊椎固定術におけるBMPの担体の検討"日本脊椎外科学会雑誌. 10(1). 165 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Minamide A.,Yamada H., et al: "Ligamentum flavum hematoma in the lumbar spine"Journal of Orthopaedic Science. 4. 376-379 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Minamide A.,Tamaki T., et al: "Experimental spinal fusion using sintered bovine bone coated with type 1 collagen and recombinant human bone morphogenetic protein-2"SPINE. 24. 1863-1870 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Minamide A.,Tamaki T., et al: "Effects of basic fibroblast growth factor on spontaneous resorption of herniated intervertebral discs. An experimental study in the rabbit"SPINE. 2. 940-945 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 南出晃人,玉置哲也 他: "焼成骨を材料とした人工椎体の開発に関する実験"日本脊椎外科学会雑誌. 9(1). 324 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 南出晃人,玉置哲也 他: "牛焼成骨(True Bone Ceramics)を用いた脊椎後側方固定術の実験的研究"日本パラプレジア医学会雑誌. 11(1). 158 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hashizume H.,Tamaki T., et al: "Changes in the extracellular matrix on the surface of sintered bovine bone implanted in the femur of a rabbit : An immunohistochemical study"Journal of Orthopaedic Science. 3. 42-53 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 南出晃人,玉置哲也 他: "人工椎体に焼成骨材料を応用した実験的研究"日本整形外科学会雑誌. 72(8). S1590 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 南出晃人,玉置哲也 他: "rhBMP-2と焼成骨を用いた脊椎後側方固定術"日本脊椎外科学会雑誌. 9(1). 292 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Minamide A.,Tamaki T., et al: "An experimental approach to spinal fusion using sintered bovine bone in a pig model"Journal of Spinal Disorders. 13(2). 156-164 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 南出晃人,玉置哲也 他: "焼成骨材料の脊椎固定術への応用に関する実験的研究"臨床整形外科. 34(4). 553-559 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 南出晃人,玉置哲也 他: "脊椎固定術におけるBMPの担体の検討"日本脊椎外科学会雑誌. 10(1). 165 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hashizume H.,Tamaki T., et al: "Changes in the extracellular matrix on the surface of sintered bovine bone implanted in the femur of a rabbit : An immunohistochemical study"Journal of Orthopaedic Science. 3. 42-53 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] 南出晃人,玉置哲也 他: "人工椎体に焼成骨材料を応用した実験的研究"日本整形外科学会雑誌. 72(8). S1590 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] 南出晃人,玉置哲也 他: "rhBMP-2と焼成骨を用いた脊椎後側方固定術"日本脊椎外科学会雑誌. 9(1). 292 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] 南出晃人,玉置哲也 他: "焼成骨を材料とした人工椎体の開発に関する実験"日本脊椎外科学会雑誌. 9(1). 324 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] 南出晃人,玉置哲也 他: "牛焼成骨(True Bone Ceramics)を用いた脊椎後側方固定術の実験的研究"日本パラプレジア医学会雑誌. 11(1). 158 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] 南出晃人、玉置哲也他: "焼成骨材料の脊椎固定術への応用に関する実験的研究"臨床整形外科. 34(4). 553-559 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Minamide A,Yoshida M,Tamaki T,et al: "Ligamentum flavum hematoma in the lumbar spine"Journal of Orthopaedic Science. 4. 376-379 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Minamide A,Tamaki T,et al: "Experimental spinal fusion using sintered bovine bone coated with type I collagen and recombinant human bone morphogenetic protein-2"Spine. 24. 1863-1870 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Minamide A,Hashizume H,Yoshida M,et al: "Effects of basic fibroblast growth factor on spontaneous resorption of herniated interveriebral discs.An experimental study in the rabbit"Spine. 24. 940-945 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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