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Development of a computor-controlled gustatory stimulator for magnetoencephalography

Research Project

Project/Area Number 11557135
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Functional basic dentistry
Research InstitutionOsaka University

Principal Investigator

YAMAMOTO Takashi  Osaka Univ., Fac. Human Sci., Professor, 大学院・人間科学研究科, 教授 (60028793)

Co-Investigator(Kenkyū-buntansha) INUI Tadashi  Osaka Univ., Fac. Human Sci., Res. Associate, 大学院・人間科学研究科, 助手 (40324735)
YAMAGUCHI Masahiko  Life-elec lab., AIST, Director, 関西センター・ライフエレクトロニクス研究ラボ, 主任研究官
TONOIEKE Mitsuo  Life-elec lab., AIST, Deputy Director, 関西センター・ライフエレクトロニクス研究ラボ, 副研究ラボ長
硲 哲崇  大阪大学, 人間科学部, 助手 (90243154)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1999: ¥6,100,000 (Direct Cost: ¥6,100,000)
Keywordstaste / stimulator / electroencephalography / 脳磁場計測 / ヒト / 脳
Research Abstract

The magnetoencephalography (MEG) is one of the non-invasive functional brain imaging techniques. MEG has good temporal resolution in comparison to functional magnetic resonance imaging (fMRI) or positron emission tomography (PET), and can give a good estimation of the localization of the activity much more precisely than electroencephalography. The purpose of the present study is to construct a convenient equipment controlled by a computer system to deliver taste solutions to the subject's tongue with accurate onset times.
A newly manufactured computer-controlled stimulus delivery system was constructed to apply taste solution and rinsing water through a Teflon tube to a flow chamber covering the anterior part of the subject's tongue. A small babble was inserted between the rinse and taste solution to prevent diffusion of fluids. The flow rate the water and stimuli was 200 ml/min. The outlet from the chamber was led to outside of the shielded room and the taste solutions and rinsing water were discarded. Taste solutions were colored red to allow their detection by an optical sensor, but water was not colored. The sensor was positioned just before the entry to the mouthpiece. This onset of taste stimulation provided a trigger signal for MEG averaging.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] N.Sakai, T.Yamamoto: "Effects of excitotoxic brain lesions on 〜"Neurobiology of Learning and Memory. 75. 128-139 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Yamamoto, N.Sakai, K.Tokita: "Characteristics of umami response in rats"Sensory Neuron. 3. 185-204 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Manabe, T.Yamamoto et al.: "Effect of diazepam binding inhibitor 〜"Behavioral Brain Research. 126. 197-204 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Shimura, K.Tokita, T.Yamamoto: "Parabrachial unit activities after the 〜"Chemical Senses. 27. 153-158 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Shimura, Y.Kamada, T.Yamamoto: "Ventral tegmental lesions reduce 〜"Behavioral Brain Research. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Sako, K.Okamoto, T.Mori, T.Yamamoto: "The hardness of food plays an important 〜"Behavioral Brain Research. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 山本 隆: "美味の構造"講談社. 246 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Sako and T.Yamamoto: "Electrophysiological and behavioral Studies on taste effectiveness of alcohols in rats"American Journal of Physiology. 276(2). R388-R396 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Sako and T.Yamamoto: "Analyses of taste nerve responses with special reference to possible receptor mechanisms of umami taste in the rat"Neuroscience Letters. 261(2). 109-112 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Yamada, N. Sako, E. Ando, M. Yamada, H. Kikuzaki and T.Yamamoto: "New bitter diterpenes, rabdosianone I and II, isolated from isodon japonicus hara"Bioscience, Biotechnology, and Biochemistry. 63(3). 524-529 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Sakai and T. Yamamoto: "Possible routes of visceral Information in the rat brain in formation of conditioned taste aversion"Neuroscience Research. 35(1). 53-61 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Kobayashi, Y. Noda, N. Matsushima, K. Nishi, H. Sawada, T. Nagatsu, D. Nakahara, R. Fukabori, Y. Yasoshima, T. Yamamoto, M. Miura, M. Kano, T. Mamiya, Y. Miyamoto and T. Nabeshima: "Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hidroxylase gene"Journal of Neuroscience. 20(6). 2418-2426 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Yamamoto and K. Sawa: "c-Fos immunoreactivity in the brainstem following gastric loads of various chemical solutions in rats"Brain Research. 866(1-2). 135-143 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Yamamoto and K. Sawa: "Comparison of c-Fos-like immunoreactivity in the brainstem following intraoral and intragastric infusions of chemical solutions in rats"Brain Research. 866(1-2). 144-151 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Yasoshima, T. Morimoto and T. Yamamoto: "Different disruptive effects on the acquisition and expression of conditioned taste aversion by blockades of amygdalar ionotropic and metabotropic glutamatergic receptor subtypes in rats"Brain Research. 869(1-2). 15-24 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Yamamoto, N. Sako and S. Maeda: "Effects of taste stimulation on β-endorphin levels in rat cerebrospinal fluid and plasma"Physiology and Behavior. 69(3). 345-350 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Manabe, K. Kuroda, M. Imaizumi, K. Inoue, N. Sako, T. Yamamoto, T. Fushiki and K. Hanai: "DBI-like activity in the rat cerebrospinal fluid after stimulation by an aversive quinine taste"Chemical Senses. 25(6). 739-746 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] E. Watanabe, A. Fujikawa, H. Matsunaga, Y. Yasoshima, N. Sako, T. Yamamoto, C. Saegusa and M. Noda: "Nav2/NaG channel is involved in control of salt-intake behavior in the CNS"Journal of Neuroscience. 20(20). 7743-7751 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Sako, S. Harada and T. Yamamoto: "Gustatory information of umami substances in three major taste nerves"Physiology and Behavior. 71(1-2). 193-198 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Sakai and T. Yamamoto: "Effects of excitotoxic brain lesions on taste-mediated odor learning in the rat"Neurobiology of Learning and Memory. 75. 128-139 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Yamamoto, N. Sakai and K. Tokita: "Characteristics of umami response in rats"Sensory Neuron. 3. 185-204 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Manabe, T. Toyoda, K. Kuroda, M. Imaizumi, T. Yamamoto and T. Fushiki: "Effect of deazepam binding inhibitor (DBI) on the fluid intake, preference and the taste reactivity in mice"Behavioral Brajn Research. 126. 197-204 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Sakai, T.Yamamoto: "Effects of excitotoxic brain lesions on 〜"Neurobiology of Learning and Memory. 75. 128-139 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Yamamoto, N.Sakai, K.Tokita: "Characteristics of umami response in rats"Sensory Neuron. 3・3. 185-204 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.Manabe, T.Yamamoto et al.: "Effect of diazepam binding inhibitor 〜"Behavioral Brain Research. 126. 197-204 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Shimura, K.Tokita, T.Yamamoto: "Parabrachial unit activities after the 〜"Chemical Senses. 27・2. 153-158 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Shimura, Y.Kamada, T.Yamamoto: "Vental tegmental lesions reduce 〜"Behavioral Brain Research. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] N.Sako, K.Okamoto, T.Mori, T.Yamamoto: "The hardness of food plays an important 〜"Behavioral Brain Research. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山本 隆: "美味の構造"講談社. 246 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Kobayashi,T.Yamamoto et al: "Modest neuropsychological deficits caused by〜"Journal of Neuroscience. 20・6. 2418-2426 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yamamot and K.Sawa: "c-Fos immunoreactivity in the brainstem〜"Brain Research. 866・1-2. 135-143 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yamamot and K.Sawa: "Comparison of c-fos-like immunoreactivity〜"Brain Research. 866・1-2. 144-151 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Yasoshima,T.Morimoto and T.Yamamoto: "Different disruptive effects on the acquisition〜"Brain Research. 869・1-2. 15-24 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yamamoto,N.Sako and S.Maeda: "Effects of taste stimulation on β-endorphin〜"Physiology and Behavior. 69・3. 345-350 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Sako,S.Harada and T.Yamamoto: "Gustatory information of umami substances〜"Physiology and Behavior. 71・1-2. 193-198 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Sako and T.Yamamoto: "Electorphysiological and behavioral Studies〜"American Journalof Physiology. 276・2. R388-R396 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N.Sako and T.Yamamoto: "Analyses of taste nerve responses with〜"Neuroscience Letters. 261・2. 109-112 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N.Sakai and T.Yamamoto: "Possible routes of visceral information〜"Neuroscience Research. 35・1. 53-61 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 永井元、山本隆 他: "脳磁場計測によるヒト味覚関連中枢応答性の〜"日本味と旬学会誌. 5・3. 371-374 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 永井元、山本隆 他: "食物関連視覚刺激のヒト中枢情報処理機構の〜"日本味と旬学会誌. 6・3. 633-636 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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