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Development of reversible antibacterial tooth surface coating material based on ion exchange mechanism

Research Project

Project/Area Number 11557144
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Conservative dentistry
Research InstitutionKagoshimaUniversity

Principal Investigator

TORII Mitsuo  Kagoshima University, Dental School, Professor, 歯学部, 教授 (30116066)

Co-Investigator(Kenkyū-buntansha) HINO Ken-ichi  Kuraray Company, Dental material Department, Manager, 歯科材料生産開発部, 部長
TSUKADA Gakuji  Kagoshima University, Dental School, Research Associate, 歯学部, 助手 (70236850)
SUWA Makoto  Kagoshima University, University Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (80206599)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥3,800,000 (Direct Cost: ¥3,800,000)
Keywordsantibacterial resin / ion-exchange / reversibility / cationic antibacterial agent / 抗菌性歯面塗布剤
Research Abstract

We planned to develop an antibacterial tooth surface coating material for caries prevention. We got Grant-in-Aid for Scientific Research [(B)(2), 1996〜1998, Project No.08457505] and Succeeded in making a prototype of antibacterial resin. This resin is mainly composed of triethylenglycol dimethacrylate (TEGDMA) and added methacrylic acid and cetylpyridinium chloride (CPC) as curable ionic exchanger and antibacterial agent respectively. CPC is retained reversibly to base resin by ionic bond. The purpose of this study is to put this antibacterial resin to use.
In former study, this resin was formulated in one liquid type. However following problems arose : This resin happened to cure spontaneously and precipitate CPC below 10 C. To prevent spontaneous curing, the formulation of resin was changed into two liquid type in spite of the lowering of handing efficiency. TEGDMA was divided into two portions, CPC and methacrylic acid were added to one portion and photoactivators were added to another portion. Consequently, spontaneous curing was prohibited.
The water sorption of this resin reached plateau within two days after water immasion and the rate was about four times more than that of control MMA resin. The rate of expansion by water sorption was also three times more than control resin. This resin dose not contain inorganic filler and the polymerization shrinkage should be pretty big. Such great water sorption rate and expansion might be favorable to decrease the polymerization contraction stress generated at the interface between resin and tooth structure. The change of Knoop hardness during water immersion was not so stable but not so inferior to control resin.
The resin showed a measure of adhesion strength to dentin without any tooth treatment.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] A.Ehara: "Antibacterial Activities and Rlease Kinetics of a Newly Developed Recoverable Controlled Agent-release System"J. Dent. Res.. 79(3). 824-828 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] A. Ehara: "Antibacterial Activities and Release Kinetics of a Newly Developed Recoverable Controlled Agent-release system"J. Dent. Res.. 39(3). 824-828 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] A.Ehara: "Antibacterial Activities and Release Kinetics of a Newly Developed Recoverable Controlled Agent-release System"J.Dental Research. 79・3. S24-S28 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] A.Ehara: "Antibacterial activities and releasekinetics of newly developed recoverable controlled agent-release system"J.Dental Research. 79(3)予定. (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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