RESEARCH ON PREDICTION OF PERIODONTAL DISEASE IN CHILDREN AND ADOLESCENTS

• Project/Area Number: 11557165
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 展開研究
• Research Field: 矯正・小児・社会系歯学
• Research Institution: OSAKA UNIVERSITY
• Principal Investigator: OOSHIMA Takashi OSAKA UNIVERSITY GRADUATE SCHOOL OF DENTISTRY, PROFESSOR, 歯学研究科, 教授 (80116003)
• Co-Investigator(Kenkyū-buntansha): KIMURA Shigenobu IWATE MEDICAL UNIVERSITY SCHOOL OF DENTISTRY, PROFESSOR, 歯学部, 教授 (10177917) ; 祖父江 鎮雄 大阪大学, 大学院・歯学研究科, 教授 (60029973)
• Project Period (FY): 1999 – 2002
• Project Status: Completed (Fiscal Year 2002)
• Budget Amount: ¥13,200,000 (Direct Cost: ¥13,200,000); Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000); Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000); Fiscal Year 2000: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 1999: ¥5,100,000 (Direct Cost: ¥5,100,000)
• Keywords: PERIODONTAL DISEASE / CHILDREN / PCR METHOD / PERIODONTOPATHIC BACTERIS / ADOLESCENTS / LONGITUDINAL STUDY / 歯周疾患

Research Abstract

The pathogenesis of periodontitis is generally accepted to be initiated by specific bacteria, however, the occurrence rate of specific periodontal bacteria in children and adolescents remains unknown. In the present study, 10 putative periodontopathic bacteria were longitudinally examined in plaque and saliva samples from 119 periodontally healthy children (2 - 15 years old) using a polymerase chain reaction method. Capnocytophaga ochracea, Capnocytophaga sputigena, and Acrinobacillus actinomycetemcomitans were frequently found in saliva, and tended to be detected in saliva for the rest of the study, whereas Porphyromonas gingivalis, Treponema denticola, and Prevotella intermedia were rarely detected. Prevotella nigrescens was more frequently detected in plaque and its prevalence increased with age. Campylobacter rectus and Eikenella corrodens were sometimes detected from both plaque and saliva, while Bacteroides forsythus was less occasionally detected in saliva. Our findings suggest that A. actinomycetemcomitans, C. ochracea, C. sputigena, P. nigrescens, C. rectus, and E. corrodens are common members of the oral microbial flora of healthy children, whereas P. gingivalis, P. intermedia, and T. denticola appear to be transient organisms.

Research Products

• [Publications] S.Kimura: "Periodontopatic Bocterial Infection in childhood"Journal of Periodontology. 73. 20-26 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] T.Ooshima: "Clinical and Microbiological changes in a child with rapid alveolar bone loss and refill"Journal of Dentistry for Children. 69. 143-147 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] KIMURA, S., OOSHIMA, T., TAKIGUCHI, M., SASAKI, Y., AMANO, A., MORISAKI, I., HAMADA, S.: "PERIODONTOPATHIC BACTERIAL INFECTION IN CHILDHOOD"JOURNAL OF PERIODONTOLOGY. 73(1). 20-26 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] OOSHIMA, T., TAKIGUCHI, M., TAMURA, M., NISHIYAMA, N.: "CLINICAL AND MICROBIOLOGOCAL CHANGES IN A CHILD WITH RAPID ALVEOLAR BONE LOSSAND REFILL"JORNAL OF DENTISTRY FOR CHILDREN. 69(2). 143-147 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] S.Kimura: "Periodontopathic bacterial infection in childhood"Journal of Periodontology. 73・1. 20-26 (2002)
• [Publications] T.Ooshima: "Clinical and microhiological changes in a child with rapid alueolar bone loss and refill"Journal of Dentistry for children. 69・2. 143-147 (2002)