• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Developmental trial of a diagnosis kit on the disease activity of alveolar bone resofptibn in periodontitis patients.

Research Project

Project/Area Number 11557168
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Periodontal dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

NAGATA Toshihiko  The University of Tokushima, School of Dentistry, Professor, 歯学部, 教授 (10127847)

Co-Investigator(Kenkyū-buntansha) ASANO Masahiro  The University of Tokushima, Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (30335822)
YAMAUCHI Noriyuki  The University of Tokushima, School of Dentistry, Research Associate, 歯学部, 助手 (10253212)
KIDO Jun-ichi  The University of Tokushima, School of Dentistry, Associate Professor, 歯学部, 助教授 (10195315)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥5,100,000 (Direct Cost: ¥5,100,000)
Keywordsgingival crevicular fluid / osteopontin / osteocalcin / calprotectin / P1CP / bone resorption / periodontal disease / 骨吸收 / 歯周炎
Research Abstract

To determine the clinical marker reflecting alveolar bone resorption in periodontal disease, osteocalcin (OCN), osteopontin (OPN), carboxy terminal propeptide of type I procollagen (P1CP), and calprotectin (CPT) were biochemically quantified using gingival crevicular fluid (GCF) from periodontitis patients. These markers appeared in GCF from periodontitis patients, whereas they were also detected a little in GCF from healthy subjects. The levels of P1CP and CPT strongly correlated with clinical inflammatory indicators such as gingival index and probing depth. Moreover, P1CP and CPT correlated with bleeding on probing (BOP) which is associated with the disease activity. OPN and OCN weakly correlated with the inflammatory markes. P1CP showed high level in GCF from bone resorptive area. Taken together, it is suggested that CPT may be a potent marker reflecting inflammatory activity and P1CP may be a potent marker reflecting bone resorption in periodontal disease.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Jun-ichi Kido: "Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease"Journal of Periodontology. 26. 653-657 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Teruo Nakamura: "The association of calprotectin level in gingival crevicular fluid with gingival index and the activities of collagenase and AST in periodontitis"Journal of Periodontology. 71. 361-367 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jun-ichi Kido: "Osteopontin in gingival crevicular fluid"Journal of Periodontal Research. 36. 328-333 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中村輝夫: "歯周炎患者の歯肉溝滲出液中に含まれるI型プロコラーゲンペプチドおよびオステオカルシンの定量分析"日本歯周病学会会誌. 44(印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 永田俊彦: "「骨代謝以上」(330-334)「先端医療シリーズ・歯周病・新しい治療を求めて」"岡田宏,石川烈,村山洋二,監修:先端医療技術研究所,東京. 536 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kido,J., Nakamura,T., Kido,R., Ohishi,K., Yamauchi,N., Kataoka,M., Nagata,T.: "Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease"J Clin Periodontol. 26 (10). 653-657 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakamura,T., Kido,J., Kido,R., Ohishi,K., Yamauchi,N., Kataoka,M., Nagata,T.: "The association of calprotectin level in gingival crevicular fluid with gingival index and the activities of collagenase and aspartate aminotransferase in adult periodontitis patients"J Periodontol. 71 (3). 361-367 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kido,J., Nakamura,T., Asahara,Y., Sawa,T., Kohri,K., Nagata,T.: "Osteopontin in gingival crevicular fluid"J Periodont Res. 36 (5). 328-333 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakamura,T., Suryono, Kido,J., Nagata,T.: "Quantitative analysis of propeptide of type I procollagen and osteocalcin in gingival crevicular fluid of periodontal disease patients"J Jpn Soc Periodontol. 44 (1) (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata,T.: "Disorders of bone metabolism"SENTAN IRYOU SIRIESE SIKAIGAKU. 330-334 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okada,H., Ishikawa,I., Murayama,y.: "SISHUBYOU"SENTAN-KENKYUSHO. 330-334 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jun-ichi Kido: "Osteopontin in gingival crevicular fluid"Journal of Periodontal Research. 36・(5). 328-333 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中村輝夫: "歯周炎患者の歯肉溝滲出液中に含まれるI型プロコラーゲンペプチドおよびオステオカルツンの定量分析"日本歯周病学会会誌. 44・(1)(印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakamura T,Kido J,Nagata T, ほか4名: "The association of calprotectin level in gingival vrevicular fluid with gingival index and the activities of collagenase and aspartate aminotrans-ferase"Journal of Periodeontology. Vol.71 No.3. 361-367 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kido J,Nagata T, ほか4名: "Osteopontin in gingival crevicular fluid."Journal of Periodontal Research. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 木戸淳一: "[白血球由来蛋白カルプロテクチンによる歯周病の診断」(第9章)"岡田宏,石川烈,村山洋二監修「歯周病・神しい治療を求めて」. 536 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中村 輝夫 ほか12名: "歯肉溝滲出液中のosteopontinおよびosteocalcinの同定と定量"日本歯周病学会会誌. 41巻 特別号. 63-63 (1999)

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1999-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi