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Basic Research on a New Generation PET system (Semiconductor Three Dimensional PET) toward Ultra Low Dose and High Spatial Resolution

Research Project

Project/Area Number 11558060
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Nuclear engineering
Research InstitutionTohoku University

Principal Investigator

ISHII Keizo  Tohoku University Graduate School of Engineering, Professr, 大学院・工学研究科, 教授 (00134065)

Co-Investigator(Kenkyū-buntansha) ITOH Masatoshi  Tohoku University Cyclotron Radioisotope Center, Professor, サイクロトロン・ラジオアイソトープセンター, 教授 (00125501)
MATSUYAMA Shigeo  Tohoku University Graduate School of Engineering,Research Associate, 大学院・工学研究科, 助手 (70219525)
YAMAZAKI Hiromichi  Tohoku University Graduate School of Engineering, Associate Professor, 大学院・工学研究科, 助教授 (00166654)
SHOJI Tadayoshi  Tohoku Institute of Technology Department of Electronics, Professor, 電子工学科, 教授 (30085394)
WATANUKI Shoichi  Tohoku University Cyclotron Radioisotope Center, Technician, サイクロトロン・ラジオアイソトープセンター, 教務職員 (30210967)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2001: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 2000: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥3,700,000 (Direct Cost: ¥3,700,000)
KeywordsUltra low Dose PET / New Generation PET / Semiconductor 3D-PET / Whole Body PET / Image Reconstruction for 3D-PET / 3次元TPE画像再構成法
Research Abstract

First, the performance of several types of semiconductor detectors was inveatigated aiming at the development of a high resolution PET system using semiconductor detectors. The detectors of TIBr of three different shapes (a thin detector 12mm^2×0.47mm, a block type detector 9mm^2×3mm and a laminated type detector 16mm^2×0.5mm×10 pieces) were made, and their performance was evaluated. The peak of 0.511ke V was obtained with the thin detector. This peak was not observed with the other TIBr detectors, due to a large noise appearing at the low energy side.
Second, the time resolution characteristics of CdTe semiconductors as detector foe PET were examined in parallel with the development on TLBr semiconductors. The time resoluhon of the CdTe semiconductor of 16mm^2×0.5mm for PET was 15ns.
From these results, it is shown that at present, the CdTe detector is suitable as detector for a small semiconductor PET, and the use of thin detector crystals allows obtaining a good time resolution.
We investigated theoretically the limit of spatial resolution for a PET system and obtained a spatial resolution limit of 0.8mm in the case of gantry diameter 25cm. Based on the present results, we built a mini-semicomductor PET, opposing the detector blocks consisting of CdTe crystals of 0.5×5×5mm^3 in four rows of two layers at 2.4mm intervals (16 detectors in total). The hyperfine structure Phantom that consisted of two or more^<22>Na hot spots of 1mm and 0.6mm diameter was tested, and the PET image of these spots was separated with a spatial resolution of 0.5mm.
This is the first high resolution PET device to date and demonstrates that considerable improvement in spatial resolution can be obtained compared to existing PET facilities.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] M.Tashiro, M.Itoh, et al.: "18F-FDG PET Mapping of Regional Brain Activity in Runners"The Journal of Sports Medicine and Physical Fitness. 41. 11-17 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Iemitsu, M.Itoh, et al.: "Regional Cardiac Glucose Metabolism During Running Measured by 3D Positron Emission Tomography in Human"Adv.Exerc.Soprts Physiol.. 17. 53-58 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Mizuta et al.: "A boundary Formation Method Using a Median Filter Processing for Attenuation Correction in 3D-PET"CYRIC Annual Report 1999. 82-90 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Tashiro, M.Itoh et al.: "18F-FDG PET Mapping of Regional Brain Activity in Runners"The Journal of Sports Medicine and Physical Fitness. 41. 11-17 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Iemitsu, M.Itoh et al.: "Regional Cardiac Glucose Metabolism During Running Measured by 3D Positron Emission Tomography in Human"Adv.Exerc.Sports Physiol.. 17. 53-58 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Mizuta et al.: "A boundary Formation Method Using a Median Filter Processing for Attenuation Correction in 3D-PET"CYRIC Annual Report 1999. 82-90 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Tashiro, M.itoh et al.: "18F-FDG PET Mapping of Regional Brain Activity in Runners"The Journal of Sports Medicine and Physical Fitness. 41. 11-17 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Iemitsu, M.Itoh, et al.: "Regional Cardiac Glucose Metabolism During Running Measured by 3D Positron Emission Tomography in Human"Adv. Exec. Sports Physiology. 17. 53-58 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mizata T.,Ishii K.,Yamagaki H.Matsuyama S.,Oishi Y.,Itoh M.,Yamaguchi K. et al: "A Boundary Formation Method Using a Median Filter Processing for Attonuation Correction in 3 D-PET"CYRIC Annual Report 1999. 82-90 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagasawa M.,Suguki A.,Ishii K.Yamagaki H.,Matsugama S. et al: "Phase Correction Analysis between EEG and MEG Simultanuously Measured by a simple System Composed of one-channel SQULD Fluxeseter and true-channel EEG device"CYRIC Annual Repoct 1999. 91-96 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 石井慶造: "3次元ポジトロンCT:3D-PET"放射線. 26・2. 27-39 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 伊藤正敏,田代学,石井慶造,窪田和雄,藤本敏彦: "三次元ポジトロンCTとその臨床応用"放射線. 26・2. 41-45 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 四月朔日聖一,藤原竹彦,石井慶造,伊藤正敏,北村圭司: "全身用ポジトロン断層撮影装置(島津:SET-2400W)の2次元および3次元データ収集画像の分解能とカウント・リカバリ係数の測定"核医学. 37巻1号. 35-41 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Tashiro,M.Itoh,T.Fujmoto,T.Fujiwara,H.Ota,K.kubota,M.Higuchi et al.: "^<18>F-FDG PET Mapping of Regional Brain Activity in Runners"The journal of sports medicine and physical fitness. (in press).

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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