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Studies on the development of diagnosis for infectious diseases among laboratory rodents

Research Project

Project/Area Number 11558096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Laboratory animal science
Research InstitutionHokkaido University

Principal Investigator

ARIKAWA Jiro  Hokkaido Univ. Grad. School of Med., Prof., 大学院・医学研究科, 教授 (10142704)

Co-Investigator(Kenkyū-buntansha) MORIMATSU Kumiko (YOSHIMATSU KUMIKO)  Hokkaido Univ. Grad School of Med, Inst., 大学院・医学研究科, 助手 (90220722)
KARIWA Hiroaki  Hokkaido Univ. Grad School of Vet med., Asso. Prof., 大学院・獣医学研究科, 助教授 (70224714)
SATO Hiroshi  Nagasaki Univ. School of Med., Prof., 医学部, 教授 (50072947)
TAKAKURA Akira  Central Institute for Experimental animals, Chief of the monitoring center, 微生物モニタリングセンター, 室長(研究職) (60167484)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2001: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥5,400,000 (Direct Cost: ¥5,400,000)
Keywordshemorrhagic fever with renal syndrome / HFRS / MHV / LCM / diagnosis / laboratory animal / zoonosis / antibody / 賢症候性出血熱
Research Abstract

1. Nucleocapsid (N) proteins of Hantaan, Seoul and Dobrava viruses were expressed by E. coli and baculovirus systems. The recombinant proteins by both systems produced enough amount of recombinant proteins and retained the anti genicity similar to those of authentic viruses. They are considered to be a ble to apply for ELISA antigen.
2. The truncated N proteins which lacked 50 amino acids at N-terminal reduced the cross reactivity to antibody to heterologous serotypes. Therefore, the truncated antigens were applied as serotyping antigen.The ELISA with the truncated antigen able to serotype of patient and rodent sera from China and Far Eastern part of Russia as determined by ordinary neutralization test.
3. Mouse hepatitis virus N protein gene was expressed by yeast system of which maximum expression was observed at 72 hours after culture. However, the antigenicity was too low to apply for ELISA antigen.
4. cDNA of N protein of lymphocytic choriomeningitis (LCM) virus were cloned from Japanese isolate (strain OQ28) and prototype strain (strain WE). The cDNAs of full length, C-terminal region and central region were independently transfected to COS cells. Although they could express recombinant proteins, amount of antigen expressed was too small to apply to ELISA.
5. Recombinant baculovirus expressing LCM virus N protein was provided from National Institute of Infectious Diseases Japan. Both the recombinant baculovirus infected SF-9 cells and Tm5 cells were found to be applicable for IFA antigen and ELISA antigen, respectively. A total of 9,840 mouse sera from 1,117 animal facility in Japan were tested for LCM virus antibody by IFA and ELISA. From these results, screening with ELISA followed by confirmation by IFA was recommended.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (109 results)

All Other

All Publications (109 results)

  • [Publications] Kariwa, H. et al.: "Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia"Virus Research. 59(2). 219-228 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Lee, B.H. et al.: "Hantavirus infection of SD rats reared in domestic laboratory animal facilities"Korean J Lab Anim Sci.. 15(1). 49-52 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogino, M. et al.: "N-acetylgalactosamine (GalNAc)-specific lectins mediate enhancement of Hantaan virus infection"Arch Virol. 144. 1765-1777 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ikegami, T. et al.: "Naturally occurring Tyzzer's disease in a calf"Veterinary Pathology. 36(3). 253-255 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ikegami, T. et al.: "Enterocolitis associated with dual infection by Clostridium piliforme and feline panleukopenia virus in three kittens"Veterinary Pathology. 36(6). 613-615 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 有川二郎: "動物由来感染症としてのハンタウイルス感染症-腎症候性出血熱とハンタウイルス肺症候群"日本獣医師会雑誌. 52. 225-229 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nozu, R. et al.: "Evaluation of PCR as a means of identification of Pasteurella pneumotropica"Experimental Animals. 48(1). 51-54 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanwa, H. et al.: "Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan"Microbiol Immunol. 44(5). 357-362 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ebihara, H. et al.: "Pathogenicity of Hantaan Virus in Newborn Mice : Genetic Reassortant Study demonstrating that a Single Amino Acid Change in Glycoprotein G1 is related to Virulence"Journal of Virology. 74(19). 9245-9255 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Wang, H. et al.: "Genetic Diversity of Hantaviruses Isolated in China and Characterization of Novel Hantaviruses Isolated from Niviventer confucianus and Rattus rattus"Virology. 278. 332-345 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murphy, M.E. et al.: "In vitro antiviral activity of lactoferrin and ribavirin upon hantavirus"Archives of Virology. 145. 1571-1582 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi, M. et al.: "Hepatic Copper Accumulation Induces DNA Strand Breaks in the Liver Cells of Long-Evans Cinnamon Strain Rats"Biochemical and Biophysical Research Communications. 276. 174-178 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kyuwa, S. et al.: "Replication of enterotropic and polytropic murine coronaviruses in cultured cell lines of mouse origin"Experimental Animals. 49(4). 251-257 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizutani, T. et al.: "The mechanism of actinomycin D-mediated increase of Borna disease virus(BDV) RNA in cells persistently infected by BDV"Microbiology and Immunology. 44(7). 597-603 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Komoro, K. et al.: "Characterization of monoclonal antibodies against Hokkaido strain tick-borne encephalitis virus"Microbiology and Immunology. 44(6). 533-536 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takakura, A. et al.: "Decontamination of human xenotransplantable tumor with mouse hepatitis virus by implantation in nude rat : a case report"Experimental Animals. 49(1). 39-41 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Goto, K. et al.: "Current Status of Helicobacter Comtamination of Laboratory Mice, Rats, Gerbil and House Musk Shrews in Japan"Current Microbiology. 41. 161-166 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高倉彰: "動物検疫の現状「ICLASモニタリングセンターの微生物検査項目の見直し」"アニテックス. 12(4). 157-161 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jin, H.K. et al.: "Mouse Mx2 protein inhibits Hantavirus but not Influenza virus replication"Archives of Virology. 146. 41-49 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Araki, K. et al.: "Truncated Hantavirus Nucleocapsid Proteins for Serotyping Hantaan, seoul, and Dobrava Hantavirus Infections"Journal of Clinical Microbiology. 39(7). 2397-2404 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arikawa, J. et al.: "Epidemiology and epizootiology of hantavirus infection in Japan"Japanese Journal of Infectious Diseases. 54(3). 95-102 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kariwa, H. et al.: "Epizootiological survey of hantavirus among rodent species in Ningxia Hui Autonomous Province, China"Japanese Journal of Veterinary Research. 49(2). 105-114 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto, H. et al.: "Microbiological Contamination in Genetically Modified animals and proposals for a microbiological Test Standard for National Universities in Japan"Experimental Animals. 50(5). 397-407 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murphy, M.E. et al.: "Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavirin upon hantavirus"Journal of Veterinary Medical Science. Jun:63(6). 637-645 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi, M. et al.: "No Significant Differences Were Observed in the Amounts of DNA Strand breaks Produced by Copper between Male amd Female Liver Cells of Long-Evans Cinnamon (LEC) Strain Rats"Journal of Veterinary Medical Science. 63(10). 1109-1113 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 有川二郎: "ハンタウイルス肺症候群"分子呼吸器病. 5(3). 48(224)-55(231) (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 有川二郎: "腎症候性出血熱"化学療法の領域. 17(5). 5(853)-9(857) (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogawa, T. et al.: "Superoxide dismutase in senescense-accelerated mouse retina"Histochemical J.. 33. 43-50 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe, Y. et al.: "Isolation of a parainfluenza virus type 3-like agent from guinea pigs"Acta Med. Nagasaki. 46(3-4). 51-18 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 渡辺洋二他: "ケージダストを使用した新しいマウス肝炎ウイルスモニタリング法の開発-遺伝子検出法の応用-"実験動物技術. 36(1). 35-40 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayasaka, D. et al.: "Evaluation of European tick-borne encephalitis virus vaccine against recent Sibenan and far-eastern subtype strains"Vaccine. 19(32). 4774-4779 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayasak, a D. et al.: "Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia"Journal of General Virology. Jun;82(6). 1319-1328 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takashima, I. et al.: "Epidemiology of tick-borne encephalitis (TBE) and phylogenetic analysis of TBE viruses in Japan and Far Eastern Russia"Japanese Journal of Infectious Diseases. Feb;54(1). 1-11 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okutani, A. et al.: "Comparison of Bacteriological, Genetic and Pathological Character between Escherichia coli O115a, C : K (B) and Citrobacter rodentium"Experimental Animals. 50. 183-186 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tian Mei Pan et al.: "Microbiological Checking on Mice and Rats of Guangdong Medical Labo-ratory Animal Center in China"Kyushu Journal of Laboratory Animals. 17. 53-57 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohsawa, K. et al.: "Sequence and genetic arrangement of the Us region of the monkey B virus (Cercopithecine herpervirus 1) genome and comparison with the Us region of other primate herpesviruses"J. Virol.. 76(3). 1516-5120 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kariwa, H. et al.: "Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia"Virus Research. 59(2). 219-228 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Lee, B. H. et al.: "Hantavirus infection of SD rats reared in domestic laboratory animal facilities"Korean J. Lab. Anim. Sci.. 15(1). 49-52 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogino, M. et al.: "N-acetylgalactosamine (GalNAc)-specific lectins mediateenhancement of Hantaan virus infection"Arch Virol.. 144. 1765-1777 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arikawa, J.: "Hantavirus infection as a zoonosis"The Journal of the Veterinary Medical Association. 52. 225-229 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ikegami, T. et al.: "Naturally occurring Tyzzer's disease in a calf"Veterinary Pathology. 36(3). 253-255 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ikegami, T. et al.: "Enterocolitis associated with dual infection by Clostridium pilforme and feline panleukopenia virus in three kittens"Veterinary Pathology. 36(6). 613-615 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nozu, R. et al.: "Evaluation of PCR as a means of identification of Pasteurella pneumotropica"Experimental Animals. 48(1). 51-54 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kariwa, H. et al.: "Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan"Microbiol. Immunol.. 445(5). 357-362 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ebihara, H. et al.: "Pathogenicity of Hantaan Virus in Newborn Mice : Genetic demonstrating that a Single Amino Acid Change in Glycopro-tein G1 is related to Virulence"Journal of Virology. 74(19). 9245-9255 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Wang, H. et al.: "Genetic Diversity of Hantaviruses Isolated in China and Characterization of Novel Hantaviruses Isolated from Niviventer confucianus and Rattus rattus"Virology. 278. 332-345 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murphy, M. E. et al.: "In vitro antiviral activity of lactoferrin and ribavirin upon hantavirus"Archives of Virology. 145. 1571-1582 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi, M. et al.: "Hepatic Copper Accumulation Induces DNA Strand Breaks in the Long-Evans Cinnamon Strain Rats"Biochemical and Biophysical Research Communications. 276. 174-178 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kyuwa, S. et al.: "Replication of enterotropic and polytropic murine coronaviruses in cultured cell lines of mouse origin"Experimental Animals. 49(4). 251-257 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizutani, T. et al.: "The mechanism of actinomycin D-mediated increase of Borna disease virus (BDV) RNA in cells persistently infected by BDV"Microbiology and Immunology. 44(7). 597-603 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Komoro, K. et al.: "Characterization of monoclonal antibodies against Hokkaido strain tick-borne encephalitis virus"Microbiology and Immunology. 44(6). 533-566 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takakura, A. et al.: "Decontamination of human xenotransplantable tumor with mouse hepatitis by implantation in nude rat: a case report"Expeimrntal Animals. 49(1). 39-41 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Goto, K et al.: "Current Status of Helicobacter Comtamination of Laboratory Mice, Rats, Gerbil, and House Musk Shrews in Japan"Current Microbiology. 41. 161-166 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takakura, A.: "Current status of animal guarantine in Japan. -Micrpbiologic testing in ICLAS monitoring center-"Laboratory Animal Technology and Science. 12(4). 157-161 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jin, H. K et al.: "Mouse Mx2 protein inhibits Hantavirus but not Influenza virus replication"Archives of Virology. 146. 41-49 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Araki, K. et al.: "Truncated Hantavirus Nucleocapsid Proteins for Serotyping Hantaan, seoul, and Dobrava Hantavirus Infections"Journal of Clonical Microbiology. 39(7). 2397-2404 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arikawa, J. et al.: "Epidemiology and epizootiology of hantavirus infection in Japan"Japanese Journal of Infectious Diseases. 54(3). 95-102 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kariwa, H. et. al.: "Epizootiological survey of hantavirus among rodent species in Ningxia-Hui AUtonomous Province, China"Japanese Journal of Veterinary Research. 49(2). 105-114 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto, H. et al.: "Microbiological Contamination in Genetically Modified animals and proposals for a microbiological Test Standard for National Universities in Japan"Expeimental Animals. 50(5). 397-407 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murphy, M. E. et al.: "Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavinn upon hantavirus"Journal of Veterinary Medical Science, Jun.. 63(6). 637-645 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi, M. et al.: "No Significant Differences Were Observed in the Amounts of DNA Strand breaks Produced by Copper between Male and Female Liver Cells of Long-Evans Cinnamon (LEG) Strain Rats"Journal of Veterinary Medical Science. 63(10). 1109-1113 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arikawa, J.: "Hantavirus pulmonary syndrome"Respiratory molecular medicine. 5(3). 48(224)-55(231) (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arikawa, J.: "Hemorohagic fever with renal syndrome"Antibiotics & chemotherapy. 17(5). 5(853)-9(857) (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogaawa, T. et al.: "Superoxide dismutase in senescense-accelerated mouse retina"Histochemical J.. 33. 43-50 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe, Y. et al.: "Isolation of a parainfluenza virus type 3-like agent from guinea pigs"Acta Med. Nagasaki. 46(3-4). 15-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe, Y. et al.: "Development of a new monitoring system for mouse hepatitis virus infection using cage dust -application of genome detection-"J. Expeimental Animal Technology. 36(1). 35-40 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayasaka, D. et al.: "Evaluation of European tick-borne encephalitis virus vaccine against recent Siberian and far-eastern subtype strains"Vaccine, Sep. 14. 19(32). 4774-4779 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayasaka, D. et al.: "Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia"J. Gen. Virol. Jun.. 82(Pt 6). 1319-1328 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takashima, I. et al.: "Epidemiology of tick-borne encephalitis (TBE) and phylogenetic analysis of TBE viruses in Japan and Far Eastern Russia"Japanese Journal of Infectious Diseases Review. Feb. 54(1). 1-11 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okutani, A. et al.: "Comparison of Bacteriological, Genetic and Pathological Character between Escherichia coli O115a, C:K (B) and Citrobacter rodentium"Experimental Animals. 50. 183-186 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tian Mei Pan et al.: "Microbiological Checking on Mice and Rats of Guangdong Animal Center in China"Kyushu Journal of Laboratory Animals. 17. 53-57 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohsawa, K. et al.: "Sequence and genetic arrangement of the Us region of the monkey B virus (Cercopithecine herpervirus 1) genome and comparison with the Us region of other primate herpesviruses"J. Virol.. 76(3). 1516-1520 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] Araki, K. et al.: "Truncated Hantavirus Nucleocapsid Proteins for Serotyping Hantaan, seoul, and Dobrava Hantavirus Infections"Journal of Clinical Microbiology. 39(7). 2397-2404 (2001)

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  • [Publications] Arikawa, J. et al.: "Epidemiology and epizootiology of hantavirus infection in Japan"Japanese Journal of Infectious Diseases. 54(3). 95-102 (2001)

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  • [Publications] Kariwa, H. et al.: "Epizootiological survey of hantavirus among rodent species in Ningxia Hui Autonomous Province, China"Japanese Journal of Veterinary Research. 49(2). 105-114 (2001)

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  • [Publications] Yamamoto, H. et al.: "Microbiological Contamination in Genetically Modified animals and proposals for a microbiological Test Standard for National Universities in Japan"Experimental Animals. 50(5). 397-407 (2001)

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  • [Publications] Murphy, M. E. et al.: "Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavirin upon hantavirus"Journal of Veterinary Medical Science. Jun ; 63(6). 637-645 (2001)

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  • [Publications] Hayashi, M. et al.: "No Significant Differences Were Observed in the Amounts of DNA Strand breaks Produced by Copper between Male amd Female Liver Cells of Long-Evans Cinnamon(LEC) Strain Rats"Japanese Journal of Veterinary Research. 63(10). 1109-1113 (2001)

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  • [Publications] 有川二郎: "ハンタウイルス肺症候群"分子呼吸器病. 5(3). 48(224)-55(231) (2001)

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  • [Publications] 有川二郎: "腎症候性出血熱"化学療法の領域. 17(5). 5(853)-9(857) (2001)

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  • [Publications] Ogawa, T. et al.: "Superoxide dismutase in senescense-accelerated mouse retina"Histochemical J.. 33. 43-50 (2001)

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  • [Publications] Watanabe, Y. et al.: "Isolation of a parainfluenza virus type 3-like agent from guinea pigs"Acta Med Nagasaki. 46(3-4). 15-18 (2001)

    • Related Report
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  • [Publications] Ohsawa, K. et al.: "Sequence and genetic arrangement of the Us region of the monkey B virus(Cercopithecine herpervirus 1) genome and comparison with the Us region of other primate herpesviruses"Journal of Virology. 76(3). 1516-1520 (2002)

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  • [Publications] 渡辺洋二 他: "ケージダストを使用した新しいマウス肝炎ウイルスモニタリング法の開発-遺伝子検出法の応用-"実験動物技術. 36(1). 35-40 (2001)

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  • [Publications] Hayasaka, D. et al.: "Evaluation of European tick-borne encephalitis virus vaccine against recent Siberian and far-eastern subtype strains"Vaccine. 19(32). 4774-4779 (2001)

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  • [Publications] Hayasaka, D. et al.: "Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia"Journal of General Virology. 82(6). 1319-1328 (2001)

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  • [Publications] Takashima, I. et al.: "Epidemiology of tick-borne encephalitis (TBE) and phylogenetic analysis of TBE viruses in Japan and Far Eastern Russia. Review"Japanese Journal of Infectious Diseases. 54(1). 1-11 (2001)

    • Related Report
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  • [Publications] Okutani, A. et al.: "Comparison of Bacteriological, Genetic and Pathological Character between Escherichia coli O115a, C : K(B) and Citrobacter rodentium"Experimental Animals. 50. 183-186 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tian Mei Pan et al.: "Microbiological Checking on Mice and Rats of Guangdong Medical Laboratory Animal Center in China"Kyushu Journal of Laboratory Animals. 17. 53-57 (2001)

    • Related Report
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  • [Publications] Kariwa, H.et al: "Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan."Microbiology and Immunology. 44(5) . 357-362 (2000)

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  • [Publications] Ebihara, K.et al: "Pathogenicity of Hantaan Virus in Newborn Mice : Genetic Reassortant Study demonstrating that a Single Amino Acid Change in Glycoprotein G1 is related to Virulence"Journal of Virology. 74(19) . 9245-9255 (2000)

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  • [Publications] Wang, H.et al: "Genetic Diversity of Hantaviruses Isolated in China and Characterization of Novel Hantaviruses Isolated from Niviventer confucianus and Rattus rattus."Virology. 278. 332-345 (2000)

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  • [Publications] Murphy, M.E.et al: "In vitro antiviral activity of lactoferrin and ribavirin upon hantavirus"Archives of Virology. 145. 1571-1582 (2000)

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  • [Publications] Hayashi, M.et al: "Hepatic Copper Accumulation Induces DNA Strand Breaks in the Liver Cells of Long-Evans Cinnamon Strain Rats "Biochemical and Biophysical Research Communications. 276. 174-178 (2000)

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  • [Publications] Jin, H.K.et al: "Mouse Mx2 protein inhibits Hantavirus but not Influenza virus replication."Virology. 146. 41-49 (2001)

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  • [Publications] Kyuwa, S.et al: "Replication of enterotropic and polytropic murine coronaviruses in cultured cell lines of mouse origin."Experimental Animals. 49(4). 251-257 (2000)

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  • [Publications] Mizutani, T.et al: "The mechanism of actinomycin D-mediated increase of Borna disease virus (BDV) RNA in cells persistently infected by BDV."Microbiology and Immunology. 44(7). 597-603 (2000)

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  • [Publications] Komoro, K.et al: "Characterization of monoclonal antibodies against Hokkaido strain tick-borne encephalitis virus."Microbiology and Immunology. 44(6). 533-536 (2000)

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  • [Publications] Takakura, A.et al: "Decontamination of Human Xenotransplantable Tumor with Mouse hepatitis virus by Implantation in Nude Rat : A Case Report."Experimental Animals. 49(1). 39-41 (2000)

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  • [Publications] 高倉彰: "動物検疫の現状「ICLASモニタリングセンターの微生物検査項目の見直し」"アニテックス. 12(4). 157-161 (2000)

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  • [Publications] Goto, K.et al: "Current Status of Helicobacter Comtamination of Laboratory Mice, Rats, Gerbil, and House Musk Shrews in Japan."Current Microbiology. 41. 161-166 (2000)

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  • [Publications] Kariwa, H., et al.: "Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia"Virus Res.. 59. 219-228 (1999)

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  • [Publications] Lee, B-H., et al: "Hantavirus infection of SD rats reared in domestic laboratory animal facilities"Korean J. of the Lab. Anim. Sci. 15(1). 49-52 (1999)

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  • [Publications] Ogino, M., et al.: "N-acetylgalactosamine (GalNAc)-specific lectins mediate enhancement of Hantaan virus infection"Arch. Virol.. 144. 1765-1777 (1999)

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  • [Publications] Ikegami, T., et al.: "Naturally occuring Tyzzer's disease in a calf"Vet. Pathol.. 36. 253-255 (1999)

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  • [Publications] Ikegami, T., et al.: "Enterocolitis associated with dural infection by Clostridium piliforme and feline panleukopenia virus in three kittens"Vet. Pathol.. 36. 613-615 (1999)

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  • [Publications] 有川 二郎: "動物由来感染症としてのハンタウイルス感染症"日獣会誌. 52. 225-229 (1999)

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  • [Publications] Takakura, A., et al.: "Decontamination of human xenotransplantable tumor with mouse hepatitis virus by implantation in nude rat : A case report"Exp. Anim. 49(1). 39-41 (2000)

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  • [Publications] Nozu, R., et al: "Evaluation of PCR as a means of identification of Pasteurella pneumotropica"Exp. Anim.. 48(1). 51-54 (1999)

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Published: 1999-04-01   Modified: 2021-11-22  

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