| Project/Area Number |
11640674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
動物生理・代謝
|
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
HAYAKAWA Yoichi Hokkaido Univ., Inst Low Tem. Sci., Asso. Prof., 低温科学研究所, 助教授 (50164926)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Kimio Hokkaido Univ., Inst Low Tem. Sci., Assist. Prof., 低温科学研究所, 助手 (30001663)
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| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Insects / cytokine / processing enzyme / growth-blocking peptide (GBP) / stress / immunity / blood coagulation factor Xa / セリンプロテアーゼ / アミノ酸配列 / 血球凝真反応 / ファクター10 / 血球凝集反応 |
|---|
| Research Abstract |
Growth-blocking peptide (GBP) is a cytokine found in insects for the first time. GBP is synthesized as a precursor protein mainly in fat body and the proGBP processing enzyme activity is present in fat body of the armyworm larvae. We purified the proGBP processing enzyme, and found that it has similar substrate specificity with Factor Xa in mammals.
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