| Project/Area Number |
11650855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
無機工業化学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAKAMURA Satoshi Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor, 生体材料工学研究所, 助手 (40227898)
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| Co-Investigator(Kenkyū-buntansha) |
OHGAKAI Masataka Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor, 生体材料工学研究所, 助手 (50223748)
YAMASHITA Kimihoro Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor, 生体材料工学研究所, 教授 (70174670)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | hydroxyapatite / Apatite / Polarization / BIomimetic / Sol-gel method / Cell culture |
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| Research Abstract |
The conformation of organic compound deposited on hydroxyapatite (HAp) ceramics was manipulated by their surface charge induced by electrical polarization. The sintered HAp ceramics were electrically polarized in a d.c. field at 4O0℃. The organic layers on the HAp ceramics were deposited from a toluene solution of phenyltrichlorosilane (PTCS). The results of contact angle measurements and IR spectroscopy clarified the organic layer containing the fragments of PTCS.The amount of the obtained layer on the positively charged surface was those on the negatively charged and non-polarized surfaces. The thickness of the layer on the non-polarized surfaces was thinner than those on the polarized surfaces, based on the depth profiles of Ca2p and Si2p. Although the deposition prepared on the non-polarized HAp surfaces from the PTCS solution was supposed to be a self-assembled layer including of phenyl-Si bond, the layers on the polarized HAp were aggregated irregularly. Consequently, the HAp ceramic surface charge induced by the polarization altered the electrostatic interaction to the organic compounds in non-aqueous system.
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