| Project/Area Number |
11660113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
FUKUI Hiroshi Kagawa University, Department of Biochemistry and Food Science, Professor, 農学部, 教授 (80026575)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Vegetable / Biofunctional component / Antitumor promoter / Antioxidant / Raji cell / Variation of content among cultivars / Edible plant / ジュート / ミョウガ / ブロッコリー / 抗酸化活性成分 / ホウレンソウ / 抗発癌プロモーター活性 / 品種間差 / Raji細胞 / ゴボウ |
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| Research Abstract |
These epidemiological predictions suggest that vegetables and fruits contain anticancer or antitumor-promoting components. Thus the physiologically functional components in vegetables could be good sources of chemopreventive agents with low-toxicity available in our daily food supply. In this research project, antitumor promoting and antioxidating components were searched in spinach, burdock, moroheiya and broccoli. The results were shown below.
1. Two kinds of monogalactosyldiacylgricerols having unsaturated fatty acids were isolated and identified as antitumor promoting components. The activity was almost the same with active components isolated from medicinal plants. In addition, the contents significantly varied among the cultivars and with culture conditions.
2. Three chlorogenic acid derivatives known as antioxidating activity were identified in burdock. The contents also varied among the cultivars.
3. Young jute (moroheiya) leaves were found to contain monogalactosyldiacylgricerols having unsaturated fatty acids and a diterpene, phytol, as antitumor promoting components. The contents increased after treatment with hot water, suggesting that these active components did not decompose during cocking.
4. Two monoacylglycerides were isolated from flower buds of broccoli as antitumor promoters. These components could be interestingly derived from monogalactosyldiacylgricerols during catabolism in human body.
These results indicate that vegetables contain many biofunctional components useful for keeping health well and that the contents of functional components significantly vary among the cultivars.
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