| Project/Area Number |
11660310
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | THE UNIVERSITY OF TOKYO |
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Principal Investigator |
KUWAHARA Masayoshi Grad.School of Agri.and Life Sci.THE UNIVERSITY OF TOKYO Associate Prof., 大学院・農学生命科学研究科, 助教授 (30205273)
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| Co-Investigator(Kenkyū-buntansha) |
TSUBONE Hirokazu Grad.School of Agri.and Life Sci.THE UNIVERSITY OF TOKYO Professor, 大学院・農学生命科学研究科, 教授 (30142095)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Cardiovascular system / Autonomic nervous system / Lipopolvsaccaride / Cytokine / Telemetry / Chronobiology / Heart rate variability / Body temperature |
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| Research Abstract |
This study was investigated roles of interleukin-1 (IL-1) on diurnal rhythms of heart rate (HR), locomotor activity (LA), and body temperature (BT). For this purpose, HR, LA, and BT were recorded from conscious and unrestrained IL-1 α/β doubly deficient (KO) and normal C57BL mice using a telemetry system. These parameters were continuously recorded from just after to 2 weeks after transmitter implantation, because we thought that the surgical stress-induced IL-1 might affect the biobehavioral activities in animals. At 1 day after implantation, HR and LA in IL-1 α/β KO mice were higher than those in C57BL mice. While BT in IL-l α/β KO mice was lower than that in C57BL mice. Moreover, a circadian rhythmicity in these parameters after implantation in IL- 1 α/β KO mice were appeared earlier than those in C57BL mice. At 2 weeks after implantation, there was no significant difference in the light-and dark-phase values of each parameter between IL-1 α/β KO and C57BL mice. However, IL- 1 α/β KO mice showed clear ultradian rhythmicity. It is thought that a phenotypical difference in biobehavioral activities between IL-1 α/β KO and C57BL mice may reflect IL-1 induced febrile and behavioral responses. These results suggest that IL-1 may play important physiological and pathophysiological roles on the biobehavioral activities.
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