| Project/Area Number |
11660317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Azabu University |
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Principal Investigator |
NINOMIYA Hiroyoshi Azabu University, School of Veterinary Medicine, Professor, 獣医学部, 教授 (00063967)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | budding / capillaries / degeneration / central necrosis / mammary tumor / resin casts / SEM / vasculature / intraarterial cushion |
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| Research Abstract |
A detailed knowledge of the vascular system of tumors is requiste to a clear understanding of tumor physiology and pathology. Accordingly, in this study examination was made of the vascular architecture of rat mammary tumors induced by dimethylbenzanthrathen by scanning electron microscoy of corrosion casts to observe the three-dimensional vascular pattern of the tumor. The result were compared with those of corresponding serial sections of India ink injected tissue. The major arteries in and around tumors appeared devoid of intra-arterial cushions which regulate blood flow. The arterial lining of resincasts was smooth just at the site where it entered the tumor. This may possibly be indication ot degeneration and loss of the smooth muscle layer in the vascular wall. Casts of capillaries were very thin from 4 to 6 micron in diameter and very few sprouts could be seen. Capillaries, frequently present in superficial regions of the tumor, formed a rich irregular fine polygonal net work. In tumor tissue in deeper regions of the tumor, this network was coarse. The absence of intra-arterial cushions and degeneration of muscle cells may thus possibly be the reason for the characteristic haemodynamics of tumors.
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