| Project/Area Number |
11670066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
SATO Yoshiharu Research Center of Health, Physical Fitness and Sports, Nagoya University Professor, 総合保健体育科学センター, 教授 (80022870)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANOUCHI Kumio Aichi Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (60135366)
OHSAWA Isao Research Center of Health, Physical Fitness and Sports, Nagoya University Associate Professor, 総合保健体育科学センター, 助教授 (10223786)
OSHIDA Yoshiharu Research Center of Health, Physical Fitness and Sports, Nagoya University Professor, 総合保健体育科学センター, 教授 (10169295)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Insulin resistance / Obesity / Mitochondrial DNA / Euglycemic clamp / autocrine / Physical training / GLUT-4 / Insulin signal / 糖輸送能 / 身体トレーニング / aging / 一酸化窒素(NO) / アデノシン / 有酸素運動 / レジスタンス運動 / 糖尿病 |
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| Research Abstract |
1) We determined the sequences of these two genes in 96 Japanese young obese adults. The physicochemical differences between the standard and the replaced amino acid residues were significantly smaller in the Cytb gene than in ATP6 one. Therefore amino acid sequences are less variable for Cytb than for ATP6 in spite of the strong mutational stand asymmetry for the Cytb gene.
2) The effect of nitric oxide (NO) on insulin resistance was studied in high-fructose-fed rats. It could be concluded that NO can improve insulin resistance induced by high-fructose feeding.
3) We examined the effects of maturation and exercise training on the gene expression and protein content of the components of post-insulin receptor signal transduction in rat skeletal muscle. Then exercise training may affect transcriptional regulation of the IRS-1 gene and posttranscriptional regulation of PI3-kinase expression.
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