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Expression of Glutamate and GABA Receptors in Brain Specimens from Intractable Pediatric Epilepsy.

Research Project

Project/Area Number 11670167
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionDokkyo University School of Medicine

Principal Investigator

YAMANOUCHI Hideo  Dokkyo University School of Medicine, PEDIATRICS, Lecturer, 医学部, 講師 (10250226)

Co-Investigator(Kenkyū-buntansha) EGUCHI Mitsuoki  Dokkyo University School of Medicine, PEDIATRICS, Professor, 医学部, 教授 (60020799)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsepilepsy / developmental disturbance / cortical dysplasia / glutamate receptors / NMDA receptors / 脳形成異常 / GABA受容体
Research Abstract

To explore the role of glutamate receptors in cortical dysplasia, we examined gene expression of NMDAR1 receptor in surgical specimens from fifteen pediatric patients with intractable epilepsy, which were pathologically diagnosed as cortical dysplasia. Histopathologically, thirteen cases were judged as grade 2 and two cases were as grade 3. In situ hybridization with NMDAR1 non-radioactive antisense riboprobe showed increased signal in large dysplastic neurons, less intensely in the nearly-normal sized neurons in dysplastic cortex, but only faint in neurons in normal appearing cortex. These results suggest that the expression of NMDAR1 receptor gene is enhanced in cortical dysplasia, speculating that excitatory condition may be related with abnormal expression of NMDAR1 receptors in cortical dysplasia.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 山内 秀雄: "Olfactory bulb dysplasia"Annals of Neurology. 46・5. 783-786 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 山内 秀雄: "Enhanced GAP-43 gene expression in cortical dysplasia"NeuroReport. 11・9. 1815-1819 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamanouchi H, et al: "Olfactory bulb dysplasia : a novel subtype of neuronal migration disorder"Annals of Neurology. 46. 783-786 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamanouchi H, et al: "Enhanced GAP-43 gene expression in cortical dysplasia"NeuroReport. 11. 1815-1819 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 山内秀雄: "Olfactory bulb dysplasia"Annals of Neurology. 46・5. 783-786 (1999)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山内秀雄: "Enhanced GAP-43 gene expression in cortical dysplasia."NeuroReport. 11・9. 1815-1819 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamanouchi H, et al.: "Enhanced GAP-43 gene expression in cortical dysplasia"Neuro Report. 11・9. 1815-1819 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hideo Yamanouchi: "Olfactory bulb dysplasia : a novel subtype of neuronal migration disorder"Annals of Neurology. 46・5. 783-786 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山内秀雄: "Cortical dysplasia"脳と神経. 51・8. 683-689 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizuguchi M: "Neurological aspects of tuberous sclerosis"Gann Monograph on Cancer Research. 46. 61-71 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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