| Project/Area Number |
11670240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKAO Nobuaki Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Assistant Professor, 大学院・医歯学総合研究科, 講師 (00126559)
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| Co-Investigator(Kenkyū-buntansha) |
IWAKI Masayoshi Aichi Medical University, Dept Ophthalmology, Professor, 医学部, 教授 (10093163)
FUJITA Koichiro Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (90053107)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Toxocara canis / Toxocara cati / ocular toxocarias / larva migrans / Mongolian gerbil / トキソカラ症 |
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| Research Abstract |
Although Toxocara canis, an important pathogen of zoonosis, tends to migrate to the eye, the precise migratory route has yet to be determined. Mongolian gerbils, Meriones unguiculatus, known as a useful animal model for human toxocariasis, were used to investigate the migration route toward the eyes. Infective larvae of T. canis were directly inoculated into the intracranial region. The hemorrhagic lesions or larvae were observed in 56.3% of cases. Histopathologically, a larva was observed in the optic nerve of gerbils 6 days after inoculation and two larvae were found in the optic chiasma in the gerbils having a hemorrhage in the retina. These results indicate that T. canis migrates from the brain to the eye through the optic nerve. Considering these data and the diversity of the appearance of larvae between the oral-administrated gerbils and the intracranial-injected gerbils, there are two phases in the migration to the retina : a hematogenous early phase and an optic nerve route late phase.
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