| Project/Area Number |
11670343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | KOCHI MEDICAL SCHOOL |
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Principal Investigator |
TAGUCHI Tetsuya KOCHI MEDICAL SCHOOL Faculty of Medicine ASSOCIATE PROFESOR, 医学部, 助教授 (40095021)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Atsushi KOCHI WOMEN'S SCHOOL DOMESTIC SCIENCE PROFESOR, 家政学部, 教授 (60178704)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | cystathionine γ-lyase / carbon tetrachloride / hepatotoxicity / rats / γ-lyase / 尿中蛋白質 |
|---|
| Research Abstract |
Cystathionine γ-lyase activity in the sera of rats subjected to experimental hepatotoxicity after intraperitoneal administration of carbon tetrachloride was measured and compared with activities of aspartate aminotransferase (GOT) and alanine aminotransferase (GPT), which have been clinically used for detecting liver damage. In the experimental subjects, serum levels of cystathionine γ-lyase showed a similar behavior to GOT and GPT, increasing markedly with respect to the controls after administration of carbon tetrachloride and reaching a maximum level at 24 hours. No such cystathionine γ-lyase activity was detected immunochemically in the control subjects. These data suggest that measurement of serum cystathionine γ-lyase activity could be used as a sensitive and specific marker of hepatic cytolysis. However, it remains necessary to confirm these results in different pathological situations affecting the human liver.
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