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Health changes of residents after the reduction of cadmium exposure

Research Project

Project/Area Number 11670345
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNagasaki University

Principal Investigator

SAITO Hiroshi  Nagasaki University School of Medicine, Professor, 医学部, 教授 (80004901)

Co-Investigator(Kenkyū-buntansha) ARISAWA Kokichi  Nagasaki University School of Medicine, Associate Professor, 医学部, 助教授 (30203384)
AOSHIMA Keiko  Toyama Medical and Pharmaceutical University, Researcher, 医学部, 助手 (20126501)
WATANABE Takao  Miyagi University of Education, Environmental Science, Professor, 教授 (20004608)
TAKAHASHI Tatsuya  Yamagata University School of Medicine, Associate Professor, 医学部, 助教授 (50304928)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordscadmium / β_2-microglobulin / Renal tubular function / blood cadmium / urine cadmium / hair cadmium / 環境中カドミウム / カドミウム環境汚染 / カドミウム腎障害 / 尿β2-マイクログロブリン / 尿β_2-マイクログロブリン / カドミウム摂取量
Research Abstract

Renal tubule dysfunction and a reduced glomerular filtration rate are predictors of mortality among persons previously exposed to environmental cadmium. However, the results also suggest that overall mortality rates in cadmium -polluted areas are not necessarily increased, because of the low mortality among those with no, or only slight, signs of low-molecular weight proteinuria. Overall cancer incidence may not be increased among residents in cadmium-polluted areas.
To evaluate the significance of cadmium (Cd) concentrations in blood (B-Cd) and hair (H-Cd) as an indicator of dose, a cross-sectional study was performed on 40 residents in a cd-polluted area, Nagasaki Prefecture, Japan, in 1996. B-Cd is a good indicator of cumulative dose many years after the reduction of environmental exposure to cadmium. H-Cd may be weakly or moderately correlated with body burden.
In 1999 and 2000, cadmium concentrations in foods ingested in 24 hours among people living in the formerly cadmium-polluted areas, Izuhara town (23 peoples aged 40~69), Nagasaki Prefecture and Kosaka town (43 peoples aged 40~69), Akita Prefecture, in Japan. Logarithmic mean values of ingested cadmium were reduced markedly in both areas. It was 58.3 in Kosaka and 54.7 microgram/day, respectively. The mean values of ingested cadmium were more than 200 microgram/day before the replacement of polluted soil from rice fields.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 有澤孝吉, 齋藤 寛: "尿中β2-マイクログロブリンおよび尿中カドミウム排泄量のreproducibilityについて"環境保健レポート. 64. 51-56 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 齋藤 寛: "カドミウム汚染水田復元工事完了によるカドミウム摂取量減少後にカドミウム土壌汚染地域住民の健康はどのように変化したか"環境保健レポート. 67. 293-295 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Xiao Jie Liu, K.Arisawa, A.Nakano, H.Saito, et al.: "Significance of cadmium concentration in flood and hair as an indicator of dose 15 years after the reduction"Toxicology Letters. 123. 134-141 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Arisawa, A.Nakano, H.Saito, et al.: "Mortality and cancer incidence among a population previously exposed to environmental cadmium"Int Arch Occup Environ Health. 74. 255-262 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 有澤 孝吉: "環境中カドミウム暴露の健康影響に関する縦断的研究"日本衛生学雑誌. 56. 463-471 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 齋藤 寛: "長崎県対馬カドミウム汚染地域住民の死亡率ならびに死亡率について"環境保健レポート. 68. 313-321 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Arisawa, H.Saito: "The reproducibility of urine beta2- microglobulin and cadmium excretion rate (In Japanese)"Kankyo Hoken Report. 64. 51-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Saito: "Health changes of residents after the reduction of cadmium (In Japanese)"Kankyo Hoken Report. 67. 293-295 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Xiao Jie Liu, Kokichi Arisawa, Atsuhiro Nakano, Hiroshi Saito, Tatsuya Takahashi, Akiko kosaka: "Significance of cadmium concentrations in blood and hair as an indicator of dose 15 years after the reduction of environmental exposure of cadmium"Toxicology Letters. 123. 134-141 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arisawa, A.Nakano, H.Saito, X.-J.Liu, M.Yokoo, M.Soda, T.Koba, T.Takahashi, K.Kinoshita: "Mortality and cancer incidence among a population previously exposed to environmental cadmium"Int Arch Occup Environ Health 74. 74. 255-262 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Arisawa: "Longitudinal and epideiolgical studies of health effects of environmental cadmium"Jap J Hyigein. 56. 463-471 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Saito: "Mortality rate and cancer incidence among Cadmium exposed residents in Japan (In Japanese)"Kankyo Hoken Report. 68. 313-321 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Xiao Jie Liu, Kokichi Arisawa, Atsuhiro Nakano, Hiroshi Saito, Tatsuya Takahashi, Akiko Kosaka: "Significance of cadmium concentrations in blood and hair as an indicator of dose 15 years after the reduction of environmental exposure to cadmium"Toxicology Letters. 123. 135-141 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Arisawa K, Nakano A, Saito H, Liu X.J, Yokoo M, Soda M, Koda T, Takahashi T, Kinoshita K.: "Mortality and cancer incidence among a population previously exposed to environmental cadmium"Int Arch Occup Environ Health. 74・4. 255-262 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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