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Utilization of Flowcytometry for Accessment of Natural Immunity as a Body Defense Mechanism in Aged People

Research Project

Project/Area Number 11670352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKagawa Nutrition University

Principal Investigator

HAYASHI Osamu  Kagawa Nutrition University, Department of Nutrition & Health, Professor, 栄養学部, 教授 (20133340)

Co-Investigator(Kenkyū-buntansha) AOYAGI Yuko  Kagawa Nutrition University, Department of Nutrition & Health, Associate, 栄養学部, 助手 (00327959)
ISHII Kyoko  Kagawa Nutrition University, Department of Nutrition & Health, Associate, 栄養学部, 助手 (30327960)
MACHIDA Kazuhiko  University Waseda, School of Human Science, Professor, 人間科学部, 教授 (00111104)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsaged people / survey / body defense mechanism / life style / physical activity / dietary habit / stress / flowcytometry / 栄養 / 生体防御機能 / 貪食 / 活性酸素 / NK活性
Research Abstract

We have studied on correlation of the life style of aged people (over 65 years old) to natural immunity as a non-specific body defense mechanism. In the present study, we focused to investigate the immune function of aged people and to utilize the resulted data for assessment of health care for aged people. The total number of subjects attended in the survey carried out for 3 years were 290 people (over 65-year old 116 male and 174 female) who lived in Nagri, Saitama prefecture. We measured their immunological function such as natural killer (NK) cell activity, phagocytosis and active oxygen production of neutrophiles, and population of lymphocyte subsets (T and B cells) analyzed with flowcytometry method along with serum biochemistry and urinalysis, in addition to questionnaire for their life style such as health practice, locomotion or physical activity, diet, smoking, and alcohol habits, and so on. We also discussed which life style is more important to maintain their good health and immune function as a body defense mechanism in aged people.
As a result, it was shown that neutrophile function (phagocytic activity and active oxygen production) was comparatively susceptible to life style, that is, significantly correlated to dietary habit, stress or moral test, and also correlated, but not significant, to grasping power in men and reflectivity. The numbers of both NK (CD16+CD56+) and NKT cells (CD3+CD56+) also correlated to dietary habit or physical activity but not to stress nor moral test. Lymphocyte function tended to correlate to good dietary or alcohol habit in men and to low BMI (not obesity) in women.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 叶雄, 信太直己, 河原直人, 町田和彦: "高齢者のストレスとその関連要因の検討"体力・栄養・免疫学雑誌. 11 2. A71-A72 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 信太直己, 叶雄, 河原直人, 町田和彦: "高齢者の肥満と生活諸機能"体力・栄養・免疫学雑誌. 11 2. A73-A74 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 石井恭子, 根本千波, 町田和彦, 林 修: "日常生活習慣と高齢者唾液中IgA抗体量について"第55回日本栄養食糧学会講演要旨集. 249 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 山崎享子, 町田和彦 他: "Flow Cytometory法を用いた好中球の貪食・殺菌能の測定と評価"日本衛生学雑誌. 56 1. 351 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] セン雅薇, 町田和彦 他: "地域高齢者のQOLとその関連要因の検討"日本衛生学雑誌. 56・1. 412 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] セン雅薇, 町田和彦 他: "埼玉県名栗村在住高齢者の居住形態とライフスタイル"日本衛生学雑誌. 55・1. 430 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. KANO, N. SHIDA, N. KAWAHARA, K. MACHIDA: "The association between stress and related factors of the rural elderly"J. Phys. Fit. Nutr. Immunol. 11(2). A71-A72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Shida, Y. KANO, N. KAWAHARA, K. MACHIDA: "Vital functions and degree of obesity in the rural elderly"J. Phys. Fit. Nutr. Immunol. 11(2). A73-A74 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. ISHII, C. NEMOTO, K, MACHIDA, O. HAYASHI: "Salivary IgA level of the rural elderly and their life style"Proceeding of 55^<th> Congress of Japanese Society of Nutrition and Food Science. 249. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. YAMAZAKI, K. MACHIDA etc.: "The measurement and evaluation of phagocytosis activity and ROS production in neutrophis using flow cytometry method"Jpn. J. Hyg.. 56 (1). 351 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ya-Wei Chan, K. MACHIDA etc.: "The association between QOL and related factors of the rural elderly"Jpn. J. Hyg.. 56 (1). 412 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ya-Wei Chan, K. MACHIDA etc.: "The pattern of inhabitation and the life style of the elderly in Nagri, Saitama"Jpn. J. Hyg.. 55 (1). 430 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 叶雄, 信太直己, 河原直人, 町田和彦: "高齢者のストレスとその関連要因の検討"体力・栄養・免疫学雑誌. 112. A71-A72 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 信太直己, 叶雄, 河原直人, 町田和彦: "高齢者の肥満と生活諸機能"体力・栄養・免疫学雑誌. 112. A73-A74 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石井恭子, 根本千波, 町田和彦, 林 修: "日常生活習慣と高齢者唾液中IgA抗体量について"第55回日本栄養・食糧学会講演要旨集. 249 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山崎享子, 町田和彦 他: "Flow Cytometory法を用いた好中球の貧食・殺菌能の測定と評価"日本衛生学雑誌. 56・1. 351 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] セン雅微, 町田和彦 他: "地域高齢者のQOLとその関連要因の検討"日本衛生学雑誌. 56・1. 412 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] セン雅微, 町田和彦 他: "埼玉県名栗村在住の高齢者の居住形態とライフスタイル"日本衛生学雑誌. 55・1. 430 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 〓雅薇,町田和彦 他: "地域高齢者のQOLとその関連要因の検討"日本衛生学雑誌. 56.1. 418 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] せん雅薇、町田和彦他: "埼玉県栗村在住の高齢者の居住形態とライフスタイル"日本衛生学雑誌. 55・1. 430 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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