The Establishment of an Objective Assessment Method of Relaxed Condition Based on Measurements about Cerebral Cortex, Autonomic Nerve Activities and Stress-related Hormones
| Project/Area Number |
11670353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nihon University |
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Principal Investigator |
HIRAYANAGI Kaname Nihon Univ., Medicine, Associate Prof., 医学部, 助教授 (20189864)
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| Co-Investigator(Kenkyū-buntansha) |
YAJIMA Kazuyoshi Nihon Univ., Medicine, Prof., 医学部, 教授 (40010029)
IWASAKI Kenichi Nihon Univ., Medicine, Assistant Prof., 医学部, 講師 (80287630)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Relaxation / Electroencephalograph / Heart rate variability / Autonomic nerve function / Hormone / Functional MRI |
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| Research Abstract |
To establish the objective assessment method of human relaxed condition, various human functions such as EEG, Autonomic nerve activities, and stress-related hormones were measured for 15 healthy subjects during the different levels of arousal or pleasantness. Caffeine and nasal catarrh tablets were taken to induce high- or low-arousal levels. Pleasant and horror videos were used to induce high- or low relaxed condition. Moreover, pleasant and unpleasant sounds were played to cause relaxed or annoying condition. Discriminant analysis revealed that respiratory rate (bpm), high-frequency [0.15-0.4Hz] power spectrum of heart rate variability (ms^2) and salivary cortisol (μg/dl) were sensitive to the assessment of the relaxed or annoying condition. The discriminant function was expressed as z =-1.63×(Respiratory rate)+0.005×(HF power spectrum)+4.74×Salivary cortisol+0.11. The error rate on the discriminant analysis was less than 20(%). The activating areas on brain cortex during relaxed or annoying condition were visually confirmed by means of functional magnetic resonance imaging.
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Report
(3 results)
Research Products
(8 results)
