| Project/Area Number |
11670356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Fukuoka University |
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Principal Investigator |
UNE Hiroshi Fukuoka University, Sch.Med., Professor, 医学部, 教授 (40122676)
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| Co-Investigator(Kenkyū-buntansha) |
MOMOSE Yoshito Fukuoka University, Scho.Med., Assistant Professor, 医学部, 助手 (20123119)
MIYAZAKI Motomobu Fukuoka University, Sch.Med., Associate Professor, 医学部, 助教授 (60299542)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Helicobacter pylori / CagA / Transmission route / Intrafamilial transmission / Transmission between spouses / mother to child transmission / Father to child transmission |
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| Research Abstract |
This study examines whether a transmission of Helicobacter pylori (H.pylori) occurs between married couples and also whether a correlation is found between a parent and an offspring that relates to the H.pylori transmission.
Design-A cross sectional study was performed among residents living in a rural area. We serologically confirmed a cytotoxin-associated protein (CagA) of H.pylori using by a recombinant CagA in addition to antibodies to H.pylori. The data was analysed using unconditional logistic regression models.
Participants-The study subjects were 1,910 volunteers between the ages of 22 and 79 years residing in this area.
Main results-A significant association in married couples on H.pylori seropositivity was observed (p<0.001), but no significant difference was recognized between them with respect to the presence of CagA (p=0.053). Concerning the relationship between a parent and an offspring on H.pylori seropositivity, the odds ratio for seropositive offsprings in a seropositive mother group was 8.08 (95% CI : 1.39-40.05) and this value was 2.93 (95% CI : 0.25-33.85) for those in a seropositive father group. As to the association between H.pylori-seropositive parents and their H.pylori-seropositive offsprings on the presence of CagA, the relationship between a mother and her offspring, 11 groups (84.6%) of 13 groups were concordance about the existence or absence of CagA compared with 7 groups (50.0%) of 14 groups in the relationship between a father and his offspring.
Conclusions-Our results suggest that maternal influence is likely to be more powerful than paternal influence on the transmission of H.pylori
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