| Project/Area Number |
11670377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of the Ryukyu |
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Principal Investigator |
HOKAMA Tomiko Faculty of Medicine, University of the Ryukyu Professor, 医学部, 教授 (60045242)
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| Co-Investigator(Kenkyū-buntansha) |
UEZU Noriko Faculty of Medicine, University of the Ryukyu Assistant Professor, 医学部, 助手 (30176581)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | sIgA / pharyngeal mucous / breast feeding |
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| Research Abstract |
Breast milk secretary immunoglobulin A (BMsIgA) has been thought to coat mucosal surface of gastrointestinal tract in recipient infants, protecting infants from invasion of pathogenic bacteria. It has been observed that the prevalence of respiratory tract infection in breastfed infant is also lower than that in formula-fed infant. We thought that surface of pharyngeal mucosa of recipient infants is also coated by BMsIgA as well as the surface of gastrointestinal tract in mucosa. In order to confirm this we estimated the level of sIgA in pharyngeal mucous among infants with different feeding methods.
The mean and standard error of the ratio of sIgA/protein in breastfed (n=18), mixed-fed (n=l5) and formula-fed infants (n=8) were 0.055±0.010, 0.065±0.017 and 0.045±0.010 respectively. There was not significant difference in those values among infants with different feeding methods.
The results showed that the levels of sIgA among infants with different feeding methods were not different. The speculation of BMsIgA binding and coating in the pharyngeal mucosa of recipient infants could not be confirmed quantitatively. Based on this preliminary study, we conclude that BMsIgA does not influence the level of sIgA of pharyngeal mucous in recipient infants.
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