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Interpretation of drug concentrations in pericardial fluid, cerebrospinal fluid and vitreous humor

Research Project

Project/Area Number 11670419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionKochi Medical School

Principal Investigator

MORIYA Fumio  Kochi Medical School, Department of Legal Medicine, Associate Professor, 医学部, 助教授 (40182274)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsForensic toxicology / Postmortem blood drug concentration / Pericardial fluid / Cerebrospinal fluid / Vitreous humor / Drug analysis / Postmortem redistribution / Gas chromatograph
Research Abstract

Drug-involved forensic autopsy cases in which cerebrospinal fluid, vitreous fluid, pericardial fluid and blood samples (pulmonary arterial and venous blood, cardiac blood, aortic blood, inferior vena caval blood and femoral venous blood) were obtained and in which no obvious putrefaction was observed were selected in this study. Although blood drug concentrations were very site dependent, drug concentrations in blood from the right cardiac chambers were quite similar to those in femoral venous blood. The correlations of drug concentrations between femoral venous blood and pericardial fluid were better than those between blood and cerebrospinal fluid/vitreous humor. However, some cases showed relatively large differences in drug concentrations between blood and pericardial fluid. Drug concentrations in femoral venous blood were compared with concentrations in average drug concentrations in cerebrospinal fluid, vitreous humor and pericardial fluid, and the average concentrations between all possible pairs among these three fluids. The ratios between average cerebrospinal fluid/pericardial fluid drug concentration and femoral venous drug concentration was very close to 1 (O.94±O.20, n=16). We established following criteria for objectively judging whether drug concentrations determined in postmortem blood are usable for toxicologic evaluation : 1) when the ratio of average cerebrospinal fluid/pericardial fluid drug concentration to blood drug concentration is within a range of 0.6-1.4, the postmortem blood drug concentration is usable for toxicologic evaluation ; and 2) when the ratio is outside the range, the average cerebrospinal fluid/pericardial fluid drug concentration should be used as an alternative to drug concentration in postmortem blood.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Fumio Moriya: "Criteria For judging whether postmortem blood drug concentrations can be used for toxicologic evaluation"Legal Medicine. 2・3. 143-151 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fumio Moriya: "Criteria for judging whether postmortem blood drug concentrations can be used for toxicologic evaluation"Legal Medicine. Vol.2-No.3. 143-151 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fumio Moriya: "Criteria for judging whether postmortem blood drug concentrations can be used for toxicologic evaluation"Legal Medicine. 2・3. 143-151 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fumio Moriya: "Pericardial Fluid as an albernative specimen to blood for postmortem toxicological analyses"Legal medicine. 1・2. 86-94 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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