| Project/Area Number |
11670453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
|
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| Research Institution | Kagoshima University |
|---|
Principal Investigator |
MATSUYAMA Takami Faculty of Medicine, Kagoshima University, Professor, 医学部, 教授 (30145479)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Noriko Faculty of Medicine, Kagoshima University, Research Associate, 医学部, 助手 (00244228)
|
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| Project Period (FY) |
1999 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
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| Keywords | HB-EGF / Rheumatoid Arthritis / Synovial cells / Apoptosis |
|---|
| Research Abstract |
1 HB-EGF was expressed in synovial fibroblasts from rheumatoid and osteoarthritis patients in addition to synovial macrophages by the analysis of RT-PCR and in situ hybridization using HB-EGF antisense RNA probe.
2 Raji cells transfected with HB-EGF did not affect the apoptosis of Jurkat cells, compared to the wild type Raji cells. However, Heparan sulfate but no chondroitin sulfate inhibited the apoptosis of Jurkat cells, suggesting the inhibitory effect of heparan sulfate binding substance on the apoptosis of Jurkat cells.
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