| Project/Area Number |
11670482
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TODA Minoru Dept pf Medicine, The University of Tokyo, Assistant, 医学部・附属病院, 助手 (80302719)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRATORI Yasushi Dept pf Medicine, The University of Tokyo, Lecturer, 医学部・附属病院, 講師 (70196624)
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| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | K-ras / pancreatic cyst / pancreatic juice / pancreatic cancer / intraductal papillary mucin-producing tumor of the pancreas / 膵がん / 膵のう胞 |
|---|
| Research Abstract |
Quantitative analysis of mutant K-ras gene in pancreatic juice was performed in a total of 317 patients. A high level of the mutant gene was detected in 39/66 (59%) cases with pancreatic carcinoma, in 33/61 (54%) cases with intraductal papillary mucin-producing tumor of the pancreas and in 26/89 (29%) cases with small cystic lesions in the pancreas. It was not detected in other cases. Therefore, these cystic lesions could represent a precursor of pancreatic neoplasms, although there were no neoplastic changes during the recent three years.
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