Mapping of genes responsible for ulcerative colitis using new microsatellite markers within the HLA region.
| Project/Area Number |
11670484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata university |
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Principal Investigator |
SUGIMURA Kazuhito Niigata Univ., Medical Hospital, 3rd Dept. of Int.Med., Instructor, 医学部・附属病院, 助手 (80270940)
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| Co-Investigator(Kenkyū-buntansha) |
ASAKURA Hitoshi Niigata Univ., Faculty of Medicine, Professor, 医学部, 教授 (20051451)
INOKO Hidetoshi Tokai Univ., Faculty of Medicine, Professor, 医学部, 教授 (10101932)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Japanese / MICA gene (major histocompatibility complex class I chain-related gene A) / Population study / STR (short tandem repeat) / Ulcerative colitis / MHCクラスI関連遺伝子 / 三塩基反復配例多型 |
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| Research Abstract |
MHC class I chain-related gene A (MICA) has been found near the HLA-B gene. The MICA molecule is exclusively expressed on gastrointestinal epithelium and recognized by intestinal epithelial gd T cells, where it exhibits a triplet repeat polymorphism in the transmembrane region. We investigated the possible correlation between MICA genetic polymorphism and ulcerative colitis (UC). Eighty-three patients with UC and 132 unrelated controls were included in this study. All subjects were Japanese. A triplet repeat polymorphism in the transmembrane region of the MICA was determined by direct sequencing procedures after amplification by a polymerase chain reaction. A significantly higher allele and phenotype frequencies of MICA A6 allele were observed in patients with UC than controls (allele frequency : Pc=0.000011, phenotype frequency : Pc =0.0049 odds ratio=2.62). A6 homozygous patients with UC showed significantly earlier onset of UC than patients without the A6 allele (Pc=0.0042). Phenotypes of MICA A6 allele in Japanese are closely related to the disease susceptibility and behavior in UC.Examinations of MICA polymorphism in other ethnic groups may provide important information about the locus of primary responsible gene for UC.
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Report
(3 results)
Research Products
(9 results)
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[Publications] Sugimura K, Masao Ota, Jun Matsuzawa, Yoshihiko Katsuyama, Kisei Ishizuka, Tutomu Mochizuki, Nobuhisa Mizuki, Terasu Homma, Hidetoshi Inoko, Hitoshi Asakura: "Triplet repeat polymorphism of MHC class I chain-related gene A (MICA) in Japanese patients with ulcerative colitis."Tsuchiya M, Matsuo Y, Kasuya Y, Muto T, eds. Gastrointestinal function, regulation and disturbances. Tokyo : Elsevier Science K.K.. (in press).
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