• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Immunological study of autoimmune pancreatitis

Research Project

Project/Area Number 11670495
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

OKAZAKI Kazuichi  Kyoto University, 医学研究科, 助教授 (70145126)

Co-Investigator(Kenkyū-buntansha) KAWANAMI Chiharu  Kyoto University, 医学研究科, 助手 (30293864)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1999: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsautoimmune / pancreatitis
Research Abstract

We observed that several autoantibodies such as antinuclear antibody (ANA), anti-lactoferrin (LF) antibody (ALF), anti-carbonic anhydrase-II (CA-II) antibody (ACA-II ), rheumatoid factor and antismooth muscle antibody were frequently detected in patients with. The high prevalence of these antibodies suggests that CA-II and LF may be the candidates for the target antigens in AIP.Although the effector cells of AIP have been poorly understood, the activated CD4+ and CD8+ T-cells bearing HLA-DR and CD45RO were increased in the peripheral blood lymphocytes (PBLs) in the patients with AIP in comparison with those in other causes of pancreatitis such as alcoholic or gallstone-related pancreatitis. CD4+ T-cells also predominantly infiltrate in the pancreas tissue over CD8+ T-cells. Similar to SjS or PSC, CD4+ T-cells showing Th1 type of immune response are predominantly involved in the development of AIP as effector cells over Th2 type CD4+ T-cells. In some patients with AIP, HLA-DR antigens a … More re expressed on the pancreatic duct cells as well as CD4+ T-cells. Neonatally thymectomized (nTx) mice subcutaneally immunized with CA-II or LF, and synergetic nude mice, transferred with seplenocytes from the disease-induced nTx-mice, developed pancreatitis as well as sialoadenitis and cholangitis, but the normal BALA/c mice did not. In our animal model using nTx-BALB/c mice and transferred nude mice, the CD4-positive cells were mainly involved in the development of pancreatitis, sialoadenitis and cholangitis, while CD8+ T-cells were never pathogenic. These findings suggested that MHC-class II restricted-autoreactive CD4+T-cells, which escape from the negative selection in the thymus, and depletion of regulatory T-cells such as CD25+ T-cells in the periphery take important roles in the development of autoimmune pancreatitis and exocrinopathy. These animal models suggest that although CD8+ T-cells may be partially involved, CD4+ T-cells take major roles in the development of experimental pancreatitis, which is consistent with human AIP. Less

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Adachi E,Okazaki K et al: "Acute pancreatitis secondary to 5-aminosali-cylic acid therapy in a patientswith ulceratiye coliti"Int J Pancreatol. 25. 219-223 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamoto Y,OkazakiK: "Autoimmune pancreatitis with F-18fluoro-2-D-glucose PET findings."Clinical N,,clear Medicine. 24. 778-780 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okazaki K,Uchida K, et al: "Autoimmune- rela ted pancreatitis is associated with autoantibodies and a Th1/Th2 responses."Gastroenterology. 118. 573-581 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchida K,Okazaki K: "Clinical evaluation of autoimmune-related pancreatitis."Am J Gastroenterol. 195. 2788-2794 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamoto Y,Okazaki K, et al.: "FDG-PET of autoimmune-related pancreatitis"Eur J Nuclear Medicine. 27. 1835-1838 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Emi Adachi, Kazuichi Okazaki, Yumi Matsushima, Hiroshi Seno, Kazushige Uchida, Hiroshi Nakase, Chiharu Kawanami, Takefumi Nakamura and Tsutomu Chiba: "Acute pancreatitis secondary to 5-aminosalicylic acid therapy in a patient with ulcerative colitis."Int J Pancreatol. 25. 219-223 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Gastric aberrant pancreas: "endoscopic ultrasonographic analysis in comparison with the histology."Gastrointest Endosc. 49. 493-497 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamoto Yuji, Sakahara H, Higashi T, Saga T, Sato N, Okazaki K, Imamura M, Konishi J: "Autoimmune pancreatitis with F-18 fluoro-2-deoxy-D- glucose PET findings."Clinical Nuclear Medicine.. 24. 778-780 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kazuichi Okazaki, Kazushige Uchida, Masaya Ohana, Hiroshi Nakase, Suguru Uose, Maki Inal, Yumi Matsushima, Kenji Katamura, Katsuyuki Ohmori, Tsutomu Chiba: "Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2 type cellular immune response."Gastroenterology. 1-10 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamoto Y, Saga T, Ishimori T, Higashi T, Mamede M, Okazaki K, Imamura M, Sakahara H, Konishi J: "FDG-PET of autoimmune -related pancreatitis : preliminary results."European Journal of Nuclear Medicine. 27. 835-1838 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchida K, Okazaki K, Konishi K, Ohana M, Takakuwa H, Hajiro K, Chiba T: "Clinical evaluation of autoimmunity-related chronic pancreatitis."Am J Gastroenterol. 95. 2788-2794 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakase H, Itani T, Mimura J, Kawasaki T, Komori H, Okazaki K, Chiba T: "Successful treatment of severe acute pancreatitis by the combination therapy of continous arterial infusion of a protease inhibitor and continuous hemofiltration : acase report."J Gastroenterol Hepatology.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okazaki K, Uchida K, Chiba T: "Review article. Recent concept of autoimmune-related pancreatitis"J Gastroenrterol. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Adachi E,Okazaki K et al: "Acute pancreatitis secondary to 5-aminosali-cylic acid therapy in a patientswith ulcerative colit"Int J Pancreatol. 25. 219-223 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakamoto Y,Okazaki K: "Autoimmune pancreatitis with F-18fluoro-2-D-glucose PET findings."Clinical N,,clear Medicine. 24. 778-780 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okazaki K, Uchida K, et al: "Autoimmune-rela ted pancreatitis is associated with autoantibodies and a Th1/Th2 responses."Gastroenterology. 118. 573-581 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Uchida K, Okazaki K: "Clinical evaluation of autoimmune-related pancreatitis."Am J Gastroenterol. 195. 2788-2794 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakamoto Y,Okazaki K, et al.: "FDG*PET of autoimmune-related pancreatitis"Eur J Nuclear Medicine. 27. 1835-1838 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Emi Adachi,Okazaki K et al.: "Acute pancreatitis secondary to 5-aminosalycylic acid therapy in a patient with ulcerative colitis"Int.J.Pancreatol. 25. 219-223 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Okazaki.K,Uchida K, et al.: "Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2 type cellular immune response"Gastroenterology. 118. 573-581 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Uchida K,Okazaki K et al.: "Clinical evaluation of autoimmunity-related chronic pancreatitis"Am.J.Gastoenterolo. (in press).

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1999-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi