| Project/Area Number |
11670506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shimane Medical University |
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Principal Investigator |
ISHIHARA Shunnji (2000) Shimane Medical University, Assistant Professor, 医学部, 助手 (80263531)
福田 亮 (1999) 島根医科大学, 医学部, 講師 (50208972)
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| Co-Investigator(Kenkyū-buntansha) |
石原 俊治 島根医科大学, 医学部, 助手 (80263531)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | Colon mucosa / TGF-β1 / DNA / methylation / methylation specific PCR |
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| Research Abstract |
Previously, we have reported that transforming growth factor-β1 (TGF-β1) production in colon mucosa is lower in the distal colon and that development of sporadic adenomas is associated with lower levels of TGF-β1. In recent studies, we investigated the prevalence of the methylation in the promoter of TGF-β1 gene by using methylation specific PCR.These have shown that prevalence of the methylation in the promoter of TGF-β1 gene gradually increased from ascending colon to the rectum. When the prevalence of the methylation in the promoter of TGF-β1 gene was compared between normal and cancer-bearing colon mucosa, the prevalence was higher in the latter. These results suggests that the methylation in the promoter of TGF-β1 gene is closely associated with site-dependent production of TGF-β1 in colon mucosa and may be related to the development of colon cancer.
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