| Project/Area Number |
11670549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University School of Medicine |
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Principal Investigator |
HARADA Riko (2001) Kurume University School of Medicine, 2nd Department of Medicine, Postdoctoral Fellow, 医学部, 助手 (50279155)
金 基哲 (1999-2000) 久留米大学, 医学部, 助手 (30279145)
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| Co-Investigator(Kenkyū-buntansha) |
TORIMURA Takuji Kurume University School of Medicine, 2nd Department of Medicine, Assistant Professor, 医学部, 講師 (60197986)
UENO Takato Kurume University, Research for Innovative Cancer Yherapy, Professor, 先端癌治療研究センター, 教授 (70176618)
緒方 理子 久留米大学, 医学部, 助手 (50279155)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | hepatocellular carcinoma / angiopoietin-1 / Tie-2 / angiogenesis / 血管新生 / angiopoietin-1 |
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| Research Abstract |
Hepatocellular carcinoma is a highly vascular tumor which overexpresses the potent angiogenic factor, vascular endothelial growth factor. Recently, Angiopoietin1 and Angiopoietin2 have been shown to exert functions in tumor angiogenesis that are distinct from vascular endothelial growth factor. To assess the potential role of angiopoietin-1 and angiopoietin-2 in tumor vascularization, we have investigated their expression pattern in hepatocellular carcinoma from 1999 to 2001.We studied 56 patients with hepatocellular carcinoma. AU patients had undergone hepatic angiography. The expression of angiopoietin- 1 and angiopoietin-2 mRNAs in hepatocellular carcinoma tissue and noncancerous liver tissue was compared by reverse transcriptase polymerase chain reaction (n=9). The expression of angiopoietin-1, angiopoietin-2, and Tie-2, their receptor was investigated by immunohistochemistry (n=47). The changes in angiopoietin-1 and angiopoietin-2 expression were evaluated in relation to tumor differentiation and changes in tumor vascularity.
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