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The elucidation of the evolution and progression of early colorectal carcinomas by the genetic alteration.

Research Project

Project/Area Number 11670552
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKurume University

Principal Investigator

TOYONAGA Atsushi  Kurume University School of Medicine, 2nd Department of Medicine, Professor, 医学部, 教授 (00098881)

Co-Investigator(Kenkyū-buntansha) KAWANO Hiroshi  Kurume University School of Medicine, 2nd Department of Medicine, Assistant, 医学部, 助手 (80258409)
MIYAZAKI Shiro  Kurume University School of Medicine, 2nd Department of Medicine, Assistant, 医学部, 助手 (60289428)
TSURUTA Osamu  Kurume University School of Medicine, 2nd Department of Medicine, Assistant, 医学部, 講師 (60197770)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
KeywordsEarly colorectal carcinoma / Diagnosis of the invasive depth / Microsatellite instability / endoscopic ultrasonography / Magnified colonoscopy / Genetic alteration / pit pattern / de novo carcinoma
Research Abstract

1. Studies in patients with early colorectal carcinoma
The selection of a therapeutic method for early colorectal carcoinomas, especially determination of the indication of endoscopic treatment for this cancer, is a clinically important. Cases of superficial colorectal cancer without lympho node metastasis are absolutely indicated for endoscopic treatment. Considering the previous reports that EMR is indicated in cases of tumors remaining in the mucosa or cancer slightly invading the submucosal layer. Therefore, we evaluated the diagnostic efficacy of the conventional, chromo, magnified colonoscopy, and endoscopic ultrasound sonography for the staging of invasive depth of early colorectal carcinomas.
2. The analysis of genetic alteration using the paraffin-embedded tissues obtained by surgical or endoscopic mucosal resection.
Recently, a lot of clinical significance between microsatellite instability and colorectal carcinomas were reported. On evaluating the results of microsatellite instabilitly from another point of view, it is thought that the altered microsatellites described a legacy of tumor progression. Therefore, the findings of microsatellite alteration may contribute to the elucidation of the evolution and progression of early colorectal carcinomas. We analyzed microsatellite alteration in an early colorectal carcinoma with four different grades of differentiation. The altered microsatellites suggested that two pathways of evolution and progression of carcinomas were present in this case. It was thought that the analysis of microsatellite alteration was very useful method for the elucidation of the evolution and progression of early colorectal carcinomas. It is necessary to investigate the analysis of microsatellite alteration in many cases with early colorectal carcinomas.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 鶴田修: "早期大腸癌肉眼分類-私の診断基準"胃と腸. 34. 22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 藤田三丈: "大腸腫瘍内視鏡的粘膜切除標本による局所根治度判定 実体顕微鏡を併用して"胃と腸. 34. 635-643 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 鶴田修: "通常内視鏡下pit観察による大腸腫瘍・非腫瘍鑑別能の検討"胃と腸. 34. 1613-1622 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Osamu Tsuruta: "Indication for endoscopic resection of submucosal colorectal carcinoma : special reference to lymph node metastasis"Diagnostic and Therapeutic Endoscopy. 6. 101-109 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Eiji Nishiwaki: "Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16^<INK4A> contributes to cell cycle regulation"Molecular and Cellular Biology. 20. 7726-7734 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fang-Yu Wang: "Macroscopic classification of early colorectal carcinoma : a comparison between Japan and China"Digestive Endosocopy. 12. 322-326 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Osamu Tsuruta: "Indication for endoscopic resection of submucosal colorectal carcinoma : special reference to lymph node metastasis"Diagnostic and Therapeutic Endoscopy. 6. 101-109 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Eiji Nishiwaki: "Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16INK4A contributes to cell cycle regulation"Molecular and Cellular Biology. 20. 7726-7734 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fang-Yu Wang: "Macroscopic classification of early colorectal carcinoma : a comparison between Japan and China"Digestive Endosocopy. 12. 322-326 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Osamu Tsuruta: "Indication for endoscopic resection of submucosal colorectal carcinoma : special reference to lympho node metastasis."Diagnostic and Therapeutic Endoscopy. 6. 101-109 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fang-yu Wang and Osamu Tsuruta: "Macroscopoc classification of early colorectal carcinoma : a comparison between Japan and China."Digestive Endoscopy. 12. 322-326 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tetsuo Miyaki,and Osamu Tsuruta: "Decreased expession of CD44, alpha-catenin, and deleted colon carcinoma and altered expression of beta-catenin in ulcerative colitis assotiated dysplasia and carcinoma, as compared with sporadic colon neoplasm."Cancer. 89. 733-740 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 鶴田 修: "早期大腸癌肉眼分類-私の診断基準"胃と腸. 34・1. 22-23 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 藤田三丈,鶴田 修: "大腸腫瘍内視鏡的粘膜切除標本による局所根治度判定"胃と腸. 3・2. 172-173 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Osamu Tsuruta: "Usefulness of the high-frequency ultrasound probe in pretherapeutic staging of superficial-type colorectal tumors"International Journal of Oncology. 13. 677-684 (1998)

    • Related Report
      1999 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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