| Project/Area Number |
11670570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOSHINO Takeshi Tokyo University Department of Assistant Hospital, Respiratory Medicine, The University of Tokyo, Professor, 医学部・附属病院, 助手 (10282659)
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| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
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| Keywords | Bronchial Asthma / Disease related gene / 5-lipoxygenase activating protein / FLAP-promoter / Polymorphism / Leukotriene Receptor / Interleukin 16 / 喘息の寛解 |
|---|
| Research Abstract |
We investigated novel polymorphism of asthma associated gene polymorphism. And we found 2 homozygotes of novel alleles in the FLAP promoter polymorphism, which showed 21 and 18 mononucleoacid repeats. There were significant difference of the 21 and 18repeats genotype frequencies between these asthmatics and control subjects. But No association was found between asthmatics and controls in the cys-LT1 receptor gene polymorphism or in the interleukin-16 promoter polymorphism.
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