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PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL SIGNIFICANCE OF ACTIVATION of FIBVRINOLYTIC CASCADE BY AIRWAY TRYPSIN-LIKE PROTEASE

Research Project

Project/Area Number 11670580
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTHE UNIVERSITY OF TOKUSHIMA

Principal Investigator

YASUOKA Susumu  THE UNIVERSITY OF TOKUSHIMA, DEPARTMENT OF NURSINNG PROFESSOR, 医療技術短期大学部, 教授 (30035414)

Co-Investigator(Kenkyū-buntansha) SANO Toshiaki  THE UNIVERSITY OF TOKUSHIMA, SCHOOL OF MEDICINE PROFESSOR, 医学部, 教授 (80154128)
NAKAMURA Yoichi  THE UNIVERSITY OF TOKUSHIMA, HOSPITAL OF SCHOOL OF MEDICINE LECTURER, 医学部・附属病院, 講師 (00237447)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsHUMAN AIRWAY TRYPSIN-LIKE PROTEASE / AIRWAY / CILIATED EPITHELIAL CELLS / FIBRINOLYTIC CASCADE / PROUROKI NASE / FIBRINOGEM / FIBROBLAST / TGF-β1 / 気道上皮細胞
Research Abstract

THIS STUDY WAS UNDERTAKEN TO CLARIFY MECHANISM OF ACTIVATION OF FIBRINOLYTIC CASCADE BY HUMAN AIRWAY TRYPSIN-LIKE PROTEASE(HAT), WHICH WE FOUND IN THE HUMAN AIRWAY, AND TO CLARIFY PATHOPHYSIOLOGICAL SIGNIFICACE OF THIS ACTIVATION.FOLLOWING RESULTS WERE OBTAINED.
1. LOCALIZATION OF HAT IN AIRWAYS : LOCALIZATION OF HAT IN THE AIRWAYS WAS IMMUNOHISTOCHEMICALLY EXAMINED USING FRESH BRONCHIAL TISSUES OBTAINED AT SURGERY.IT WAS SHOWN THAT POSITIVE REACTION WAS FOUND IN BRONCHIAL CILIATED EPITHELIAL CELLS.THIS RESULT INDICATES THAT HAT IS BIOSYNTHESIZED IN AIRWAY EPITHELIAL CELLS.
2. ABILITY TO HYDROLYZE ENDOGENOUS PROTEINS OF HAT : IT WAS SHOWN BY SDS-POLYACRYLAMIDE GEL ELECTROPHORESIS THAT HAT CLEAVES FIBRINIGEN, ESPECIALLY ITS α -CHAIN, AND FIBRIN, BUT DOES NOT PLASMONIGEN ITSELF, AND THAT HAT CONVERTS PROUROKINASE INTO UROKINASE BY LIMITED PROTEOLYSIS.
3. EFFECT OF HAT ON GROWTH AND FUNCTION OF LUNG AND BRONCHIAL FIBROBLASTS : IT WAS SHOWN IN VITRO SYSTEM THAT HAT ENHANCES GROWTH OF BOTH LUNG AND BRONCHIAL FIBROBLASTS, AND IT ALSO ENHANCES PRODUCTION OF TGF-β1 BY BOTH THE FIBROBLASTS.
4. CONCLUSION : IT IS POSTULATED THAT HAT IS BIOSYNTHESIZED IN AIRWAY EPITHELIAL CELLS, AND IS THOUGHT TO BE RELATED TO ACTIVATION OF FIBRINOLYTIC CASCADE BY ACTIVATION OF PROUROKINASE IN THE AIRWAY.IT IS ALSO POSTULATED THAT HAT IS RELATED TO AMPLIFICATION OF REMODELING OF AIRWAY TISSUES IN CRONIC INFLAMATORY DISEASES, BY ACTIVATION OF FIBRINOLYTIC CASCADE, AND BY ENHANCEMENT OF GROWTH AND FUNCTION OF FIBROBLASTS.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Syunji Nakano: "Characteristics of the protease activity in synovial fluid from patients with rheumatoid arthitis and osteoarthritis"Clinical and experimental Rheumatology. 17. 52-60 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mika Kurokawa: "Influenza virus overcomes apoptosis by rapid multiplication"International Journal of Molecular Medicine. 3. 527-530 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Susumu Yasuoka: "Fibrinogenolytic activity and prourokinase-activating activity of human airway trypsin-like protease(HAT)"Proceeding of airway secretion research. 1. 21-34 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yuuichi Ikeda: "Cathepsins B and synovial fluids from patients with rheumatoid arthritis and the effect of cathepsins B on the activation of pro-urokinase"The Journal of Medical Investigation. 47・1〜2. 61-75 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masako Takahashi: "Localization of human airway trypsin-like protease in the airway : An immunohistochemical study."Histochem Cell Biology. (in Press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 安岡劭: "喀痰からの情報"メディカルビュー社. 200 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SYUJI NAKANO: "CHARACTERISTICS OF THE PROTEASE ACTIITY IN SYNOVIAL FLUID FROM PATIENTS WITH RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS"CLIN EXP RHEUMATOLOGY. 17. 52-60 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] MIKA KUROKAWA: "INFLUENZA VIRUS OERCOMES APOPTOSIS BY RAPID MULTIPLICATION"INTERNATIONAL J MOL MED. 3. 527-530 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SUSUMU YASUOKA: "FIBRINOGENOLYTIC ACTIVITY AND PROUROKINASE-ACTIVATING ACTIITY OF HUMAN AIRWAY TRYPSIN-LIKE PROTEASE(HAT)"PROCEEDING OF A AIRWAY SECRETION RESEARCH. 1. 21-34 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] YUICHI IKEDA: "CATHEPSIN B AND SYNOVIAL FLUIDS FROM PATIENTS WITH RHEUMATOID ARTHRITIS AND THE EFFECT OF CATHEPSIN 8 ON THE ACTIVATION OF PROUROKINASE"J MED INVEST. 47. 61-75 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] MASAKO TAKAHASHI: "LOCALIZATION OF HUMAN AIRWAY TRYPSIN-LIKE PROTEASE IN THE AIRWAY.AN HISTOCHEMICAL STUDY"HISTOCHEM CELL BIOLOGY. (in PRES).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SUSUMU YASUOKA: "INFORMATIONS FROM SPUTUM, MONOGRAPH"MEDICAL VIEW Co, OSAKA, TOKYO. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masako Takahashi: "Localization of human airway trypsin-like protease in the airway : An immunohistochemical study."Histochem Cell Biology. (in Press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 安岡劭: "喀痰からの情報"メディカルビュー社. 200 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Syunji Nakano: "Characteristics of the protease activity in synovial fluid from patients with rheumatoid arthritis and osteoarthritis"Clinical and experimental Rheumatology. 17. 52-60 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mika Kurokawa: "Influenza virus overcomes apoptosis by rapid multiplication"International Journal of Molecular Medicine. 3. 527-530 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Susumu Yasuoka: "Fibrinogenolytic activity and prourokinase-activating of human airway trypsin-like protease(HAT)"Proceeding of airway secretion research. 1. 21-34 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yuuichi Ikeda: "Cathepsis B and synovial fluids from patients with rheumatoid arthritis and the effect of cathepsins B on the activation of pro-urokinase"The Journal of Medical Investigation. 47・1〜2. 61-75 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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