| Project/Area Number |
11670619
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Shinshu University |
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Principal Investigator |
KOH Chang-sung Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (80143981)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | multiple sclerosis / Theiler's virus / demyelination / sex bias / タイラー脳脊髄炎ウイルス / 脱髄疾患 / 性差 / 男性ホルモン / タイラー脳脊髄炎ウィルス / B7-1 / B7-2 |
|---|
| Research Abstract |
We examined the role of sex hormones in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD). Incidence of TMEV-IDD were significantly increased in castrated male BALB/c mice compared to sham operated control male BALB/c mice. Increased incidence of TMEV-IDD in castrated male BALB/c mice were significantly suppressed when the animals were treated with testosterone or 5-a-androstan. TMEV-specific DTH, TNF-a producing ' cells, and INF-gproducing cells were significantly increased in castrated male BALB/c male mice compared to sham operated control male BALB/c mice. RT-PCR revealed significantly increased levels of messenger RNA of TNF-a and INF-g in castrated male BALB/c mice compared to sham operated control male BALB/c mice. Treatment of testosterone or 5-a-androstan reduced increased levels of messenger RNA of TNF-a and INF-g in castrated male BALB/c mice. These findings suggest that testosterone and 5-a-androstan may have suppressive effect in the development of TMEV-IDD, affecting to producing of inflammatory cytokines.
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