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Vascular effects of angiotensin (1-7) and its contribution to the effect of the cardiovascular drugs

Research Project

Project/Area Number 11670697
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionYokohama City University

Principal Investigator

UEDA Shinichiro  Yokohama City University School of Medicine, Research Associate., 医学部, 助手 (80285105)

Co-Investigator(Kenkyū-buntansha) GOTO Eiji  Yokohama City University School of Medicine, Assistant Prof, 医学部, 助教授 (30153753)
TOYA Yoshiyuki  Yokohama City University School of Medicine, Assistant Prof, 医学部, 講師 (30237143)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsangiotensin (1-7) / angiotensin II / angiotensin I / ACE / nitric oxide / ACE inhibitor / ブラジキニン / アンジオテンシンII / アンジオテンシン変換酵素 / 本態性高血圧 / アンジオテンシン(1-7) / 一酸化窒素 / 前腕抵抗血管
Research Abstract

We investigated effects of angiotensin peptide in human forearm resistant vessles in vivo. We also established the assay system of angiotensin peptides and evaluated effects of angiotensin converting enzyme (ACE) inhibitor on plasma concentration of angiotensin (1-7) in normotensive and hypertensive subjects.
1. Angiotensin (1-7) had no direct vasodilating effect in human forearm resistant. However, angiotensin (1-7) antagonized angiotensin II but not noradrenaline induced vasoconstriction, which suggested that angiotensin (1-7) might act as an endogenous angiotensin II antagonist.
2. Angiotensin (1-7) significantly potentiated bradykinin-induced vasodilatation in human forearm resistant vessels. This effect was abolised by L-NMMA, nitric oxide synthase inhibitor, which suggested the involvement of nitric oxide in this interaction
3. Angiotensin (1-7) induced potentiation of the vasodilating effect of bradykinin was also abolished by the single dose of ACE inhibitor., which suggested ACE dependent effect of angiotensin (1-7) on bradykinin. Angiotensin (1-7) also significantly attenuated angiotensin I-induced vasoconstriction. These results suggested that angiotensin (1-7) might be an endogenous ACE inhibitor in man.
4. Chronic treatment with ACE inhibitors was associated with significant increased levels of plasma angiotensin (1-7) levels but not decreased levels of plasma angiotensin II in patients with essenstila hypertension. Angiotensin (1-7) may contribute to maintenance of hypotensive effect of ACE inhibitors in man.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Ueda S et al: "Angiotensin (1-7) attenuates vasoconstriction evokted by angiotensin II but not noradrenaline in man"Hypertension. 35. 998-1001 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ueda S et al: "Angiotensin (1-7) potentiates vasodilating effect of bradykinin in man"J Hypertens. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ueda S, Masumori-Maemoto S, Ashino K, Nagahara T, Gotoh E, Umemura S, Ishii M.: "Angiotensin-(1-7) attenuates vasoconstriction evoked by angiotensin II but not by noradrenaline in man."Hypertension. 35. 998-1001 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ueda S, Masumori-Maemoto S, Wada A, Umemura S: "Angiotensin (1-7) potentiates vasodilating effect of bradykinin in humans"J Hypertens. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ueda S, et al.: "Angiotensin (1-7) potentiates vasodilating effect of bradykinin in humans."16^<th> International Society of Hypertension Chicago, USA August. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ueda S et al: "Chronic treatment of ACE inhibitors is associated with increased plasma concentration of angiotensin (1-7) in patients with essenstial hypertension."FASEB meeting, Aulando, USA, April. (accepted). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ueda et al: "Angiotensin-(1-7) attenuates vasoconstriction evoked by angiotensn II but not noradrenaline in man"Hypertension. 35. 998-1001 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda et al: "Angiotensin-(1-7) potentiates vasodilating effect of bradykinin in man"Journal of Hypertension. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda S.et al.: "Angiotensin(1-7)attenuates vasoconstriction Evoked by AII but not by NA in man."Hyper tension. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 植田真一郎 ほか: "アンジオテンシン(1-7)はブラジキニンの血管拡張作用を増強する"Therapeutic Research. (印刷中).

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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