| Project/Area Number |
11670713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Women's Medical University School of Medicine |
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Principal Investigator |
SUGAWARA Motoaki Tokyo Women's Medical University School of Medicine, Department of Cardiovascular Sciences, Professor, 医学部, 教授 (60010914)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Keisuke Nihon Kohden Corp., R & D Center, Assistant Manager, 開発部, 係長
TAKAKI Hiroshi National Cardiovascular Center Research Institute, Senior Staff, 室長 (60216629)
NIKI Kiyomi Tokyo Women's Medical University School of Medicine, Department of Cardiovascular Sciences, Research Associate, 医学部, 助手 (40218095)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | cardiac function / aorta / exercise tolerance / blood momentum / systole / diastole / ventricle / wave intensity |
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| Research Abstract |
The aim of this study was to evaluate aortic blood momentum near end-ejection as an index of exercise tolerance. We developed a method of grading the effect of the aortic blood momentum, using the phase loop of left ventricular pressure P (dP/dt vs. P relation). The method was applied to 6 patients with ischemic heart disease before and after exercise. The patients with stronger effect of the aortic blood momentum showed higher exercise tolerance. The method was also applied to 8 patients before and after coronary artery bypass grafting surgery. The effect of the aortic blood momentum was significantly higher after surgery than before surgery.
We also clarified that the effect of aortic blood momentum near end-ejection generates the second positive peak of arterial wave intensity, which is a new hemodynamic index of ventriculo-arterial interaction. We measured wave intensity in patients with heart disease using an ultrasonic method. The second peak of wave intensity in patients with mitral regurgitation diminished or disappeared, since the effect of the aortic momentum was decreased or absent.
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