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Enhancement of graft-vs-leukemia (GVL) effect by monocyte-derived dendritic cells following cord blood transplantation

Research Project

Project/Area Number 11670755
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionMie University

Principal Investigator

AZUMA Eiichi  Mie University, Hospital, Associate Professor, 医学部・附属病院, 助教授 (50211008)

Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordscord blood transplantation / graft-vs-leukemia (GVL) effect / dendritic cell / 臍帯血移植 / 臍帯血単球 / GVL効果
Research Abstract

In cord blood transplantation, graft-vs-host disease (GVHD) is mild and graft-vs-leukemia (GVL) effect may not take place. There are several cell types that may induce GVHD.Dendritic cells (DC) present allogeneic peptide to T cells that attack host. In this project, we examined whether DC may enhance allo-reaction, ie.GVHD/GVL.Since our preliminary data showed that DC could be induced from cord blood monocytes, we examined the characteristics of cord blood monocytes. Cord blood monocytes showed lower antigen-presentig capacity than adult blood, and functionally immature (Pediatr Int. in press. 2001), Next, we examined the mechanisms of T-cell apoptosis following antigen priming (Eur.J.Immunol. 2000), because T-cells primed with DC may apoptose early in the post-transplant. Then, we investigated T-cell recovery following allogeneic hematopoietic stem cell transplantation. We found that naive T-cell recovery is inversely correlated with donor age. These data suggest that T-cell recovery is prompt following cord blood transplantation (Brit.J.Haematol. 2000). Thus, T-cell following cord blood transplantation can be used to induce GVL effect with the help of DC.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Hirayama M,Azuma E, et al.: "The reconstitution of CD45RBhiCD4+naive T cells is inversely correlated with donor age in murine allogeneic haematopoietic stem cell transplantation"British Journal of Haematology. 111. 700-707 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Qing-Shen Li.,Azuma E.,Komada Y, et al.: "Activation-induced T cell death occurs at Gl A phase of the cell cycle"European Journal of Immunology. 30. 3329-3337 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Jiang Q,Azuma E, et al.: "Functional immaturity of cord blood monocytes as detected by impaired response to hepatocyte growth factor"Pediatrics International. 43(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirayama M, Azuma E, et al.: "The reconstitution of CD45RBhiCD4+ naive T cells is inversely correlated with donor age in murine allogeneic haematopoietic stem cell transplantation"Brit.J.Haematol. 111. 700-7 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Qing-Shen Li, Azuma E, Komada Y, et al.: "Activation-induced T cell death occurs at GIA phase of the cell cycle"Eur.J.Immunol. 30. 3329-37 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Jiang Q, Azuma E, et al.: "Functional immaturity of cord blood monocytes as detected by impaired response to hepatocyte growth factor"Pediatr Int.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirayama M,Azuma E, et al.: "The reconstitution of CD45RBhiCD4+ naive T cells is inversely correlated with donor age in murine allogeneic haematopoietic stem cell transplantation"British Journal of Haematology. 111. 700-707 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Qing-Shen Li,Azuma E.Komada Y, et al.: "Activation-induced T cell death occurs at Gl A phase of the cell cycle"European Journal of Immunology. 30. 3329-3337 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Jiang Q,Azuma E, et al.: "Functional immaturity of cord blood monocytes as detected by impaired response to hepatocyte growth factor"Pediatrics International. 43(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kumamoto T,Azuma E,et al.: "Human dendritic cells express the thrombopoietin receptor,c-Mpl"Brit J Haematol. 105. 1025-1033 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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