| Project/Area Number |
11670797
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
MOMMA Kazuo Tokyo Women's Medical University. Pediatr., 医学部, 教授 (80075233)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUOKA Rumiko Tokyo Women's Medical University, essor Pediatr. Cardiol, Assistant, 医学部, 助手 (50120051)
|
|---|
| Project Period (FY) |
1999 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
|---|
| Keywords | Fetus / Premature Baby / Ductus Arteriosus / Nitric Oxide / Prostaglandin / 動脈管開存 / プロスタグランジン |
|---|
| Research Abstract |
Previous studies have established hypoxemia and prostaglandins as mechanisms of dilatation of fetal ductus arteriosus. Based on these theories, indomethacin has been used to close the ductus in premature infants. More potent treatment is needed because of insufficient effects of indomethacin in closing premature ductus. This study was intended to establish more potent treatment of the premature ductus. We studied the effects of an inhibitor of nitric oxide synthesis : L-NAME to the fetal ductus in near-term and preterm rats. Only minimal ductus constriction was induced by L-NAME in near-term fetus. In contrast, more severe ductal constriction was induced by L-NAME in preterm rats. Prominent synergistic ductal constriction was induced in near-term fetal rats by indomethacin and L-NAME.These results show that combined administration of indomethacin and L-NAME is potent treatment to close ductus arteriosus in premature babies.
Fetal Circulation, Ductus Arteriosus, Nitric Oxide, Prostaglandins, L-NAME, indomethacin,
|
