• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role for macrophage migration inhibitory factor (MIF) in the skin and contribution to the skin diseases.

Research Project

Project/Area Number 11670813
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

TADAMICHI Shimizu  Hokkaido University Medical Hospital, Assistant Prof., 医学部・附属病院, 講師 (70260396)

Co-Investigator(Kenkyū-buntansha) JUN Nishihira  Central Research Institute, Hokkaido University Graduate School, Associated Prof., 大学院・医学研究科, 助教授 (30189302)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsmacrophage / cytokine / skin / inflammation / atopy / ultraviolet / wound / 腫瘍 / 乾癬 / メラノーマ / 増殖因子
Research Abstract

Macrophage migration inhibitory factor (MIF) was the first lymphokine reported to prevent random migration of macrophages and recruit them at inflammatory loci. Recent findings demonstrated that MIF functions as an initiator of inflammation via regulation of a number of proinflammatory cytokines. Furthermore, MIF has been reevaluated as a proinflammatory cytokine, pituitary-derived hormone, and glucocorticoid-induced immunomodulator
1. We have demonstrated that MIF function as a novel growth factor that stimulates incessant growth and invasion of melanoma concomitant with neovascularization (Biochem Biophys Res Commun 1999). 2. Enhancement of MIF production in the skin by ultraviolet B exposure in vivo and in vitro (J Invest Dermatol, 1999). MIF expression is profoundly involved in cutaneous inflammatory and immune responses in a variety of immunogenic skin disorders 3. MIF production by PBMC from AD patients was significantly elevated in comparison with non-atopic healthy individuals. … More In addition, Con A stimulated more MIF production by PBMC from AD patients than those from non-atopic individuals (J Allergy Clin Immunol 1999). MIF production by PBMCs of psoriatic patients was significantly elevated, whereas the production of MIF protein relatively decreased in psoriatic skin lesions and no apparent vascular damages was observed in the studies of in situ hybridization (J Invest Dermatol 2001). We suggested that elevated MIF productivity of infiltrating immunocytes concomitant with increased serum MIF contents promotes a lesional immunologic disorder of psoriatic skin in combination with other cytokines, and causes inflammation and thickening of the skin. We recently demonstrated that the mean levels of MIF in the sera were significantly elevated in patients with extensive alopecia areata (J Invest Dermatol 2002). We suggest that inflammatory cytokines may be implicated in the induction or continuation of damage of hair follicles and that MIF may play an important part in the pathophysiology of inflammatory hair loss conditons such as alopecia areata. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Shimizu T. et al.: "Enhanced expression of macrophage migration inhibitory factor (MIF) associated with extended psoriasis"J. Invest Dermatol. 116. 989-990 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T. et al.: "Increased macrophage migration inhibitory factor (MIF) in the sera of patients with extensive alopecia areata"J. Invest Dermatol. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe H, Shimizu T et al.: "Aging fibroblasts show a diminished response to macrophage migration inhibitory factor (MIF)-induced interleukin-8 expression"Proc 12th Jpn-Korea Joint Meeting of Dermatology. 269-272 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamaguchi E et al.: "Macrophage migration inhibitory factor (MIF) in bronchial asthma"Clin Exp Allergy. 30. 1244-1249 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Abe R et al.: "Enhancement of macrophage migration inhibitory factor (MIF) expression in injured epidermis and cultured fibroblasts"Biochim Biophys Acta. 1500. 1-9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T. et al.: "High expression of macrophage migration inhibitory factor in human melanoma cells and its role in tumor cell growth and angiogenesis"Biochem Biophys Res Commun. 264. 751-758 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T et al.: "ultraviolet radiation upregulates the production of macrophage migration inhibitory factor (MIF) in human epidermal keratinocytes"J Invest Dermatol. 112. 210-215 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T et al.: "Increased production of macrophage migration in hibitory factor by PBMCs of atopic dermatitis"J Allergy Clin Immunol. 104. 659-664 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T et al.: "α-Thrombin stimulates expression of macrophage migration inhibitory factor (MIF) in skin fibroblasts"Semin Thromb Hemost. 25. 569-573 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 清水忠道(分担): "皮膚病研究治療フォーラム・皮膚病治療の最近のトピックス"局所免疫療法による円形脱毛症の治療経験 -血中マクロファージ遊走阻止因子の変動-. 210-215 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T et al.: "High macrophage migration inhibitory factor (MIF) serum levels associated with extended psoriasis"J Invest Dermatol. 116. 989-990 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T et al.: "Increased macrophage migraiton inhibitory Factor (MIF) in the sera of patients with extensive alopecia areata"J Invest Dermatol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe H, Shimizu T et al.: "Aging fibroblasts show a diminished response to macrophage migration inhibitory factor (MIF)-induced interleukin-8 expression"Proc 12th Jpn-Korea Joint Meeting of Dermatology. 269-272 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Abe R, Shimizu T, et al.: "Enhancement of macrophage migraiton inhibitory factor (MIF) expression in injured epidermis and cultured fibroblasts"Biochim Biophy Acta. 1500. 1-9 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamaguchi E, Nishihara J, Shimizu T, et al.: "Macrophage migration inhibitory factor (MIF) in bronchial asthma"Clin Exp Allergy. 30. 1244-1249 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T, et al.: "Ultraviolet B radiation up-regulates the expression of macrophage migration inhibitory factor (MIF) in human epidermal keratinocytes"J Invest Dermatol. 112. 210-215 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T, et al.: "High expression of macrophage migration inhibitory factor in human melanoma cells and its role in tumor cell growth and angiogenesis"Biochem Biophys Res Commun. 264. 751-758 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T, et al.: "Increased production of macrophage migration inhibitory factor by PBMCs of atopic dermatitis"J Allergy Clin Immunol. 104. 659-664 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T, et al.: "α-Thrombin stimulates expression of macrophage migration inhibitory factor (MIF) in skin fibroblasts"Semin Thromb Hemost. 25. 569-573 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu T et al.: "Enhanced expression of macrophage migration inhibitory factor (MIF) associated with extended psoriasis"J Invest Dermatol. 116. 989-990 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shimizu T et al.: "Increased macrophage migration inhibitory factor (MIF) in the sera of patients with exlonsive alopecia areata"J Invest Dermatol. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Shimizu T et al.: "Diagnosis of Werner Syndrome by immunoblot analysis"Clin Exp Dermatol. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] 阿部理一郎: "Enhancement of macrophage migration inhibitory factor (MIF) expression in injured epidermis and cultured fibroblastss."Biochim Biophy Acta. 1500. 1-9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 山口悦郎: "Macrophage migration inhibitory factor (MIF) in bronchial asthma"Clin Exp Allergy. 30. 1244-1249 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 清水忠道: "Enhanced expression of macrophage migration inhibitory factor (MIF) associated with extended psoriasis"J Invest Dermatol. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 清水忠道: "局所免疫療法による円形脱毛症の治療経験-血中マクロファージ遊走阻止因子の変動-"皮膚病研究・治療フォーラム 雑誌. 1. 7-11 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimizu T., et al.: "High expression of macrophage migration inhibitory factor in human melanoma cells and its role in tumor cell growth and anjiogenesis"Biochem Biophys Res Commun. 264. 751-758 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu, T., et al.: "Ultraviolet β radiation up-regulates the production of macrophage migration inhibitory factor (MIF) in human epidermal keratinocytes"J Invest Dermatol. 112. 210-215 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu, T., et al.: "Increased production of macrophage migration inhibitory factor by PBMCs of atopic dermatitis"J Allergy Clin Immunol. 104. 659-664 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu, T., et al.: "α-Thrombin stimulates expression of macrophage migration inhibitory factor (MIF) in skin fibroblasts"Semin Thromb Heamost. 25. 569-573 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Abe R., Shimizu, T., et al.: "Enhancement of macrophage migration inhibitory factor (MIF) expression in injured epidermis and cultured fibroblasts"Biochim Biophys Acta. 1500. 1-9 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamaguchi, E., et al.: "Macrophage migration inhibitory factor (MIF) in bronchial asthma"Clin Exp Allergy. (in press).

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1999-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi