| Project/Area Number |
11670819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
|
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| Research Institution | Niigata University |
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Principal Investigator |
KAWAI Kazuhiro UNIVERSITY MEDICAL HOSPITAL, NIIGATA UNIVERSITY, Lecturer, 医学部・付属病院, 講師 (90242411)
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| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | γδ T cell / T cell development / Homing / Dendritic epidermal T cell / ホーシング / サイトカイン |
|---|
| Research Abstract |
Intraepithelial T cells of the murine skin, called dendritic epidermal T cells (DETC), express exclusively an invariant (Vγ3-Jγ1/Vδ1-Dδ2-Jδ2)γδ TCR. Fetal thymic precursors of DETC immigrate to the skin before birth, and in adult mice T cells expressing the canonical Vγ3 TCR identical to that of DETC are not found in other lymphoid or epithelial tissues. This study showed that DETC precursors migrate to the gut as well as to the skin during fetal periods, but preferentially survive and expand in the skin after birth. Because the ligand for the Vγ3 TCR was expressed only in the skin, "peripheral selection" of the homogeneous epidermal γδ T cell repertoire may be mediated by Vγ3 TCR signaling upon the recognition of the self-ligand.
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