| Project/Area Number |
11670837
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
ONO Tamomichi Kumomoto University, Medicine Department of Dermatology, Prof., 医学部・皮膚科学, 教授 (10040586)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAYASHIMA Kenichi Kumomoto University, Medicine Department of hospitals in affiliation, assistant, 医学部附属病院, 助手 (70264299)
EGAWA Kiyofumi Kumomoto University, Medicine Department of hospitals in affiliation, lecturer, 医学部附属病院, 講師 (50183215)
|
|---|
| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | dermal melanocyte / blue nevus / blood vessel / actmic elastosis / 悪性黒色腫 / ヒト真皮メラノサイト / 弾力線維 / Lato onset dermal melanocytosis |
|---|
| Research Abstract |
Active dermal melanocytes are present in normal human skin even in aged individuals, though they are few in number.
Inactive dermal melanocytes can be identified through morphological analysis, but through immunohistopathological analysis verifying the MART-1 positive cells. Future studies are necessary to quantify inactive dermal melanocyte.
The dermal melanocytes with perivascular distribution strongly points to the diagnosis of blue nevus.
A variant form of aquired bilateral nevus Ota-like macules present actinic elastosis in dematohistopathological analysis.
The advanced glycation end products of Maillard reaction are strongly correlated to the formation of actinic elastosis, and are accumulated in the modified elastic fibers. Future studies on the formation of reactive oxygen species during actinic elastosis formation and its correlation to dermal melanocytes are necessary.
|
