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Human Damal Melaoocyte and Dermal Melanocytosis

Research Project

Project/Area Number 11670837
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKumamoto University

Principal Investigator

ONO Tamomichi  Kumomoto University, Medicine Department of Dermatology, Prof., 医学部・皮膚科学, 教授 (10040586)

Co-Investigator(Kenkyū-buntansha) KAYASHIMA Kenichi  Kumomoto University, Medicine Department of hospitals in affiliation, assistant, 医学部附属病院, 助手 (70264299)
EGAWA Kiyofumi  Kumomoto University, Medicine Department of hospitals in affiliation, lecturer, 医学部附属病院, 講師 (50183215)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsdermal melanocyte / blue nevus / blood vessel / actmic elastosis / 悪性黒色腫 / ヒト真皮メラノサイト / 弾力線維 / Lato onset dermal melanocytosis
Research Abstract

Active dermal melanocytes are present in normal human skin even in aged individuals, though they are few in number.
Inactive dermal melanocytes can be identified through morphological analysis, but through immunohistopathological analysis verifying the MART-1 positive cells. Future studies are necessary to quantify inactive dermal melanocyte.
The dermal melanocytes with perivascular distribution strongly points to the diagnosis of blue nevus.
A variant form of aquired bilateral nevus Ota-like macules present actinic elastosis in dematohistopathological analysis.
The advanced glycation end products of Maillard reaction are strongly correlated to the formation of actinic elastosis, and are accumulated in the modified elastic fibers. Future studies on the formation of reactive oxygen species during actinic elastosis formation and its correlation to dermal melanocytes are necessary.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report

Research Products

(28 results)

All Other

All Publications (28 results)

  • [Publications] T Kageshita, T Matsui, S Hirai, Y Fukuda, T Ono: "Hypercalcaemia in melanoma patients associated with increased levels of parathyroid hormone related protein"Melanoma Researcb. 9. 69-73 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Kageshita, A Yamamoto, N Yamazaki, K Ishihara, T Ono: "Low frequency of neutralizing antibodies against natural interon-β during abjuvant therapy for Japanese patients with melanoma"Journal of Dermatological Science. 19. 208-212 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Itoh, S Linn, T Ono, M Yamaizumi: "Reinvestigation of the Classification of Five Cell Strains of Xeroderma Pigmentosum Group E eith Reclassification of Three of Them"THE JOURNAL OF INVESTIGATIVE DERMTOLOGY. 114(5). 1022-1029 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S Wakasugi, T Kageshita, T Ono: "Metastatic melanoma to the palatine tonsil with a favourable prognosis"British Journal of Dermatology. 145. 327-329 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Ishihara, T Ono: "Analusis of the Vascularity of an Atelocollagen Sponge Substitute Dermis In the Human"The Journal of Dermatology. 28(7). 360-368 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Kageshita, Y Kawakami, T Ono: "Clinical significance of MART-1 and HLA-A2 expression and CD8+T cell infiltration in melanocytic lesions in HLA-A2 phenotype patients"Journal of Dermatological Science. 25. 36-44 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C M Hayashi, R Nagai, K Miyazaki, F Hayase, T Araki, T Ono, S Horiuchi: "Conversion of Amadori Products of the Maillard Reaction to N-(carboxymethyl)lysine by Short-Term Heating : Possible Detection of Artifacts by Immunohistochemistry"Laboratory Investigation. 82(6). 795-807 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Kageshita, T Matsui, S Hirai, Y Fukuda, T Ono: "Hypercalcaemia in melanoma patients associated with increased levels of parathyroid hormone related protein"Melanoma Research. 9. 69-73 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Kageshita, A Yamamoto, N Yamazaki, K Ishihara, T Ono: "Low frequency of neutralizing antibodies against natural interon-β during abjuvant therapy for Japanese patients with melanoma"Journal of Dermatological Science. 19. 208-212 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Itoh, S Linn, T Ono, M Yamaizumi: "Reinvestigation of the Classification of Five Cell Strains of Xerodema Pigmentosum Group E eith Reclassification of Three of Them"THE JOURNAL OF INVESTIGATIVE DERMATOLOGY. 114(5). 1022-1029 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S Wakasugi, T Kageshita, T Ono: "Metastatic melanoma to the palatine tonsil with a favourable prognosis"British Journal of Dermatology. 145. 327-329 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Ishihara, T Ono: "Analusis of the Vascularity of an Atelocollagen Sponge Substitute Dermis in the Human"The Journal of Dermatology. 28(7). 360-368 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Kageshita, Y Kawakami, T Ono: "Clinical significance of MART-1 and HLA-A2 expression and CD8+ T cell infiltration in melanocytic lesions in HLA-A2 phenotype patients"Journal of Dermatological Science. 25. 36-44 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] CM Hayashi, R Nagai, K Miyazaki, F Hayase, T Araki, T Ono, S Horiuchi: "Conversion of Amadori Products of the Maillard Reaction to N-(carboxymethiyl)lysine by Short-Term Heating-Possible Detection of Artifacts by Immunohistochemistry"Laboratory Investigation. 82(6). 795-807 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomomichi Ono: "SEBORRHEIC KERATOSIS・SENILE KERATOSIS"Reprinted from the Asian Medical Journal. 43(8). 385-389 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuyoshi Ishihara: "Degenerated Neurilemoma"Reprinted from the Journal of Dermatology. 28(4). 221-225 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toshiro Kageshita: "Clinical significance of MARI-1 and HLA-A2 expression and CD8+T cell infiltration in melanocytic lesions in HLA-A2 Phenotype Patients"Journal of Dermatological Science. 25. 36-44 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Keishi Maruo: "Regressing Merkell cell carciroma-a case showing replacement of tomour cells by foamy cells"British Journal of Dermatology. 142. 1184-1189 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuyoshi Ishihara: "Sentinel Lymph Nodes study in 30 Cases of Melanoma"Reprinted from the Journal of Dermatology. 28(7). 347-352 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Seiji Wakasugi: "Metastatic melanoma to the palatine tonsil with a favourable Prognosis"British Journal of Dermatology. 145. 327-329 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kageshita T,HambyCV,Hirai S,Kimura T,Ono T,Ferrone S: "Differential clinical significance of αVβ3 expression in primary lesions of acral lentiginous melanoma and in primary lesions of other melanoma histotypes."Int.J.Cancer. 89. 153-159 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kageshita T,HambyCV,Hirai S,Kimura T,Ono T,Ferrone S: "αVβ3 expression on blood vessels and tumor cells in primary melanoma lesions; differential association with tumor proguression and clinical prognosis."Cancer Immunol Immunother. 49. 314-318 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toshiki Itoh,Stuart Linn,Tomomichi Ono and Masaru Yamaizumi: "Reinvestigation of the classification of Five Cell Strains of Xeroderma Pigmentosum Group E with Reclassification of Three of Them"THE Journal of investigative Dermatology. 114(5). 1022-1029 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tomomichi Ono: "SEBORRHEIC KERATOSIS・SENILE KERATOSIS"Asian Medical Journal. 43(8). 35-38 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsui T.: "Hypercalcinoma in Patient with Malignant Melanoma Arising in Congenital Giant Pigmented Nevus"Dermatology. 197. 65-68 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] EGAWA K.: "Pigmented viral warts:a clinical and histopathologiacal study in cluding human Papillomavirus typing"British Journal Dermatology. 138・3. 381-389 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kageshita T.: "Hypercalcaemia in meranoma patients associated with increased levels of parathyroid normonerelated protein"Melanoma Research. 9. 69-73 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suenaga Y.: "Increased Serum Levels of 5-Scysteinyldopa and Intercellular Adnesion Molecure-1 in a patient Nitn a Ucen'ne Amelanotic Metastacig fronaprionary Vaginal Matignant Melanoma"Gynecologic Oncology. 72. 107-110 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-03-31   Modified: 2016-04-21  

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