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The Treatment of Atopic Dermatitis with PUVA Photochemotherapy : Clinical and Experimental Studies in Patients and Model Mice

Research Project

Project/Area Number 11670854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKansai Medical University

Principal Investigator

HORIO Takeshi  Kansai Medical University, Department of Dermatology, professor, 医学部, 教授 (90026914)

Co-Investigator(Kenkyū-buntansha) INOUE Yohko  Kansai Medical University, Department of Dermatology, assistant, 医学部, 助手 (60278611)
HASHIMOTO Hiroko  Kansai Medical University, Department of Dermatology, assistant, 医学部, 講師 (70257955)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsatopic dermatitis / ultraviolet therapy / PUVA therapy / NC / Nga mouse / 光化学療法
Research Abstract

Recently, the number of adult patients with severe atopic dermatitis is increasing in our clinic. For more than 10 years, we have treated these patients with oral 8-methoxypsoralen and whole body exposures to UVA (systemic PUVA therapy). In the present study, we surveyed the treated patients in order to establish the systemic PUVA therapy in Japanese adult patients with severe atopic patients. Patients were hospitalized, and given orally 30mg of 8-MOP and subsequently irradiated with 2〜6J/cm^2-UVA three times a week. Most of patients received 10 to 30 time-PUVA therapy and approximately 100 J/cm^2 of UVA in total. Severity scores of atopic dermatitis linearly decreased until 12 treatments, and reached plateau thereafter. No adverse effects occurred. In next experiments, we examined the therapeutic effects of PUVA treatment on the spontaneously developed dermatitis in NC/Nga model mice of atopic dermatitis. Photochemotherapy was done 3 times a week for 4 weeks. Skin changes began to improve by 3 treatments, and did not recur even 4 weeks after discontinuation of PUVA therapy. Collectively, systemic PUVA therapy seems to be a useful modality for the treatment of severe atopic dermatitis.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Yoshimura-Mishima M, et al.: "Suppressive effect of ultraviolet (UVB and PUVA) radiation on superantigen production by staphylococcus aureus."Journal of Dermatological Science. 19. 31-36 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Miyauchi-Hashimoto H, et al.: "Ultraviolet radiation-induced suppression of natural killer cell activity is enhanced in xeroderma pigmentosum group A (XPA) model mice."Journal of Investigative Dermatology. 112. 965-970 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto H, et al.: "Evaluation of apoptotic cells induced by ultraviolet light B radiation in epidermal sheets stained by the TUNEL technique."Journal of Investigative Dermatology. 113. 802-807 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kuwamoto K, et al.: "Possible involvement of enhanced prostaglandin E_2 production in the photosensitivity in xeroderma pigmentosum group A model mice."Journal of Investigative Dermatology. 114. 241-246 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Adachi Y, et al.: "Successful treatment of lichen myxoedematosus with PUVA photochmotherapy."Photodermatology, Photoimmunology & Photomedicine. 16. 229-231 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Horio T, et al.: "Indications and action mechanisms of phototherapy."Journal of Dermatological Science. 23. S17-S21 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 堀尾武: "今日の治療指針,1999"医学書院. 1 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 堀尾武: "生物の光障害とその防御機構"共立出版. 15 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshimura-Mishima M, et al.: "Suppressive effect of ultraviolet (UVB and PUVA) radiation on superantigen production by staphylococcus aureus."Journal of Dermatological Science. 19. 31-36 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Miyauchi-Hashimoto H, et al.: "Ultraviolet radiation-induced suppression of natural killer cell activity is enhanced in xeroderma pigmentosum group A (XPA) model mice."Journal of Investigative Dermatology. 112. 965-970 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okamoto H, et al.: "Evaluation of apoptotic cells induced by ultraviolet light B radiation in epidermal sheets stained by the TUNEL technique."Journal of Investigative Dermatology. 113. 802-807 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kuwamoto K, et al.: "Possible involvement of enhanced prostaglandin E_2 production in the photosensitivity in xeroderma pigmentosum group A model mice."Journal of Investigative Dermatology. 114. 241-246 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Adachi Y, et al.: "Successful treatment of lichen myxoedematosus with PUVA photochemotherapy."Photodermatology, Photoimmunology & Photomedicine. 16. 229-231 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Horio T, et al.: "Indications and action mechanisms of phototherapy."Journal of Dermatological Science. 23. S17-S21 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshimura-Mishima M, et al.: "Suppressive effect of ultraviolet (UVB and PUVA) radiation on superantigen production by staphylococcus aureus."Journal of Dermatological Science. 19. 31-36 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Miyauchi-Hashimoto H, et al.: "Ultraviolet radiation-induced suppression of natural killer cell activity is enhanced in xeroderma pigmentosum group A (XPA) model mice."Journal of Investigative Dermatology. 112. 965-970 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okamoto H, et al.: "Evaluation of apoptotic cells induced by ultraviolet light B radiation in epidermal sheets stained by the TUNEL technique."Journal of Investigative Dermatology. 113. 802-807 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kuwamoto K, et al.: "Possible involvement of enhanced prostaglandin E_2 production in the photosensitivity in xeroderma pigmentosum group A model mice."Journal of Investigative Dermatology. 114. 241-246 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Adachi Y, et al.: "Successful treatment of lichen myxoedematosus with PUVA photochemotherapy."Photodermatology, Photoimmunology & Photomedicine. 16. 229-231 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Horio T, et al.: "Indications and action mechanisms of phototherapy."Journal of Dermatological Science. 23. S17-S21 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 堀尾武: "今日の治療指針,1999"医学書院. 1 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 堀尾武: "生物の光障害とその防御機構"共立出版. 15 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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