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セロトニンアナログ^<18>F-メチルトリプトファンを用いたうつ病発症機序の基礎的研究

Research Project

Project/Area Number 11670868
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

ENDO Keigo  Gunma University School of Medicine, Professor, 医学部, 教授 (10115800)

Co-Investigator(Kenkyū-buntansha) INOUE Tomio  Gunma University School of Medicine, Asscociate Professor, 医学部, 助教授 (80134295)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsα-methyl tryptophan / ^<18>F-α-methyl tryptophan (^<18>FAMTP) / Radiosynthesis / Serotonin metabolism / Tumor-detecting agent / F^<18>-αメチルタイロシン / パーキンソン病 / 分裂病 / うつ病 / セロトニン / ^<18>Fα-メチルトリプトファン
Research Abstract

F-18 alphamethyltryptophan (^<18>FAMTP) which is newly synthesized at our institute with use of Cyclotron system, is one of F-18 labeled amino acid reflecting the amino acid metabolism. The aim of this study was to synthesize the alpha-methyltryptophan with 18F positron nuclide and use this labeled molecule to investigate the potential utility of imaging diagnosis for neurotransmitter malfunction related with serotonin metabolism. Synthesis of ^<18>FAMTP was performed by direct electrophilic fluorination. In animal experiments, A volume of 100ul containing 370kBq of ^<18>FAMTP was injected into BALB/C female mice to measure bio-distribution at 10 minutes, 30 minutes and 60 minutes. By dissecting mice at each time, high uptakes were seen at heart, kidney and bone. Uptake at kidney at early time means rapid washout from kidney. High uptake in bone which is not like a ^<18>FAMT suggested that ^<18>FAMTP is unstable in vivo and resulted in high free ^<18>F ion. One characteristic is high uptake in heart. that suggest serotonic metabolism are taking place in heart muscle

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Tomiyoshi Katsumi: "Metabolic Studies of 18-a-methyltyrosine in mice bering colorectal carcinoma LS-180"Anti-Cancer Drugs. 10. 329-336 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 三国雅彦: "感情障害におけるアミン代謝並びに糖代謝の脳画像学的解析"精神薬療基金研究年報. 31. 173-178 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue Tomio: "Biodistribution stduies on L-3-[Fluorine-18] fluoro-a-metyltyrosine : a potential tumor -detecting agent."J.Nucl.Med.. 39. 663-667 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amano Shigeko: "In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer."J.Nucl.Med.. 39. 1424-1427 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Katsumi Tomiyoshi.: "Metabolic Studies of 18-a-methyltyrosine in mice bering colorectal carcinoma LS-180"Anti-Cancer Drugs. 10. 329-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tomio Inoue.: "Biodistribution stduies on L-3-[Fluorine-18]fluoro -a-metyltyrosine : a potential tumor -detecting agent."J.Nucl.Med.. 39. 663-667 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shigeko Amano.: "In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer."J.Nucl.Med.. 39. 1424-1427 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tomiyoshi Katsumi: "Metabolic Studies of 18-a-methyltyrosine in mice bering colorectal carcinoma LS-180"Anti-Cancer Drugs. 10. 329-336 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 三国雅彦: "感情障害におけるアミン代謝並びに糖代謝の脳画像学的解析"精神薬療基金研究年報. 31. 173-178 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue Tomio: "Biodistribution stduies on L-3-[Fluorine-18] fluoro-a-metyltyrosine : a potential tumor -detecting agent."J.Nucl.Med.. 39. 663-667 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Amano Shigeko: "In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer."J.Nucl.Med.. 39. 1424-1427 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Katsumi Tomiyoshi: "Metabolic studies of [^<18>F-α-methyl]tyrosine in mice bearing colorectal carcinoma LS-180"Anti-Cancer Drugs. 10. 329-336 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tomio Inoue: "Accuracy of standardized uptake value measured by simultaneous emission and transmission scanning in PET oncology"Nuclear Meidicne Communications. 20. 849-857 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tomio Inoue: "^<18>Fα-methyl tyrosine PET studies in patients with brain tumors"J Nucl Med. 40. 399-405 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sale Alyafei: "Biodistribution studies of the ^<186>Re complex of 3-amino-1-hydroxypropylidene-1,1-bisphosphonic acid in mice"Nuclear Medicine Communications. 20. 551-557 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tomio Inoue: "Biodistribution studies on L-3-[Fluorine-18]Fluoro α-methyl tyrosine:A potential tumor-detecting agent"J Nucl Med. 39. 663-667 (1998)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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